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WormBase Tree Display for Gene: WBGene00008082

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Name Class

WBGene00008082SMapS_parentSequenceC44B9
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classcom
Allele (101)
StrainWBStrain00032782
WBStrain00007756
WBStrain00007765
WBStrain00007807
RNASeq_FPKM (74)
GO_annotation00061816
00061817
00061818
Contained_in_operonCEOP3883
Ortholog (18)
ParalogWBGene00009770
Structured_descriptionConcise_descriptioncom-1 encodes an ortholog of budding yeast Sae2p, Arabidopsis AtCOM1, and human RBBP8 (CTIP; OMIM:604124) and C20orf151; like its yeast ortholog, COM-1 is probably required for completing meiotic recombination; meiotic chromosomes in com-1 mutants pair normally, but form irregular chromatin aggregates instead of diakinesis bivalents; while meiotic DNA double-strand breaks (DSBs) are formed, they appear to persist or undergo improper repair, with numerous chromosomal fragments being revealed by REC-8 depletion; conversely, suppression of DSBs by a spo-11 mutation also suppresses the diakinetic com-1 phenotype, and suppression by mre-11 increases com-1 mutant fertility; despite the presence of DSBs, the recombination protein RAD-51, which is known to associate with single-stranded (ss) DNA flanking DSBs, does not localize to meiotic chromosomes in com-1 mutants; exposure of com-1 mutants to gamma-radiation, however, induces RAD-51 foci, which suggests that the failure of RAD-51 to load is specific to meiotic (SPO-11-generated) DSBs; these data suggest that COM-1 helps generate ssDNA tails upon which RAD-51 can bind, after which RAD-51 migrates to homologous DNA tracts and triggers meiotic recombination; com-1 mutants grow and live normally (possibly because of maternally contributed COM-1) but are sterile; the C-terminal-most ~100 residues of COM-1 are strongly conserved, while COM-1's N-terminal ~400 residues have low sequence complexity.Paper_evidenceWBPaper00031197
WBPaper00031198
Person_evidenceWBPerson1819
Curator_confirmedWBPerson567
Date_last_updated18 Nov 2007 00:00:00
Automated_descriptionPredicted to enable damaged DNA binding activity. Predicted to be involved in DNA double-strand break processing involved in repair via single-strand annealing. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Is an ortholog of human RBBP8 (RB binding protein 8, endonuclease).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070013Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9891)
Molecular_infoCorresponding_CDSC44B9.5
Corresponding_CDS_historyC44B9.5:wp135
C44B9.5:wp200
Corresponding_transcriptC44B9.5.1
Other_sequenceJI482943.1
CJC01556_1
Associated_featureWBsf994183
WBsf1015872
WBsf225773
Experimental_infoRNAi_resultWBRNAi00042439Inferred_automaticallyRNAi_primary
WBRNAi00006169Inferred_automaticallyRNAi_primary
Expr_patternExpr1027979
Expr1033510
Expr1146428
Expr2010448
Expr2028688
Microarray_results (18)
Expression_cluster (110)
Interaction (24)
Map_infoMapIIIPosition5.56963Error0.007343
PositivePositive_cloneC44B9Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00012854
WBPaper00031197
WBPaper00037751
WBPaper00042018
WBPaper00044981
WBPaper00048211
WBPaper00054279
WBPaper00059751
WBPaper00060105
WBPaper00061254
WBPaper00061632
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene