WormBase Tree Display for Gene: WBGene00000050

WBGene00000050 SMap: S_parent: Sequence: D2092
  Identity: Version: 1
    Name: CGC_name: acr-11 Person_evidence: WBPerson1430
      Sequence_name: D2092.3
      Molecular_name: D2092.3
        D2092.3.1
        CE09102
      Other_name: CELE_D2092.3 Accession_evidence: NDB BX284601
      Public_name: acr-11
    DB_info: Database: AceView gene 1H198
        WormQTL gene WBGene00000050
        WormFlux gene WBGene00000050
        NDB locus_tag CELE_D2092.3
        Panther gene CAEEL|WormBase=WBGene00000050|UniProtKB=P91197
          family PTHR18945
        NCBI gene 191599
        RefSeq protein NM_059505.2
        TrEMBL UniProtAcc P91197
        UniProt_GCRP UniProtAcc P91197
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acr
    Allele (45)
    Strain: WBStrain00031963
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog (45)
    Paralog (100)
    Structured_description: Concise_description: A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions. Paper_evidence: WBPaper00005223
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable acetylcholine receptor activity; excitatory extracellular ligand-gated monoatomic ion channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in chemical synaptic transmission. Predicted to be located in neuron projection and synapse. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:12217 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:7474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1960)
  Molecular_info: Corresponding_CDS: D2092.3
    Corresponding_transcript: D2092.3.1
    Other_sequence: JI482048.1
      JO468908.1
      Acan_isotig17242
      JI177628.1
      JI182272.1
    Associated_feature: WBsf649250
      WBsf219611
  Experimental_info: RNAi_result: WBRNAi00043516 Inferred_automatically: RNAi_primary
      WBRNAi00102757 Inferred_automatically: RNAi_primary
      WBRNAi00113432 Inferred_automatically: RNAi_primary
      WBRNAi00003293 Inferred_automatically: RNAi_primary
      WBRNAi00066390 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1023679
      Expr1147510
      Expr2009179
      Expr2027418
    Drives_construct: WBCnstr00037768
    Construct_product: WBCnstr00037768
    Microarray_results (18)
    Expression_cluster (62)
    Interaction: WBInteraction000163500
      WBInteraction000211264
      WBInteraction000232397
      WBInteraction000387314
      WBInteraction000392230
      WBInteraction000411228
      WBInteraction000441842
      WBInteraction000457445
  Map_info: Map: I Position: 1.25616 Error: 0.003426
    Positive: Positive_clone: D2092 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4955
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene