WormBase Tree Display for Gene: WBGene00000073
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| WBGene00000073 | SMap | S_parent | Sequence | F57F5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | add-2 | |||||||
| Sequence_name | F57F5.4 | ||||||||
| Molecular_name | F57F5.4a | ||||||||
| F57F5.4a.1 | |||||||||
| CE06002 | |||||||||
| F57F5.4b | |||||||||
| CE40075 | |||||||||
| F57F5.4b.1 | |||||||||
| Other_name | CELE_F57F5.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | add-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | add | ||||||||
| Allele (59) | |||||||||
| Strain | WBStrain00032713 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00000072 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | add-2 encodes a protein containing an alpha-adducin-like head domain that while highly similar in sequence to the head domain of vertebrate and Drosophila adducins, atypically resides at the C-, rather than N-, terminus of the protein; by homology, ADD-2 is predicted to be a cell membrane-associated cytoskeletal protein that mediates cytoskeletal rearrangements in response to activation of signal transduction cascades; as loss of add-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of ADD-2 in C. elegans development and/or behavior is not yet known. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00004651 | |||||||||
| WBPaper00005654 | |||||||||
| WBPaper00010897 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity. Predicted to be located in cytoskeleton; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); and familial combined hyperlipidemia. Is an ortholog of human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2986 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243,HGNC:244) | ||||
| DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243,HGNC:244) | ||||||
| DOID:11044 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:0081361 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:245) | ||||||
| DOID:1936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| Molecular_info | Corresponding_CDS | F57F5.4a | |||||||
| F57F5.4b | |||||||||
| Corresponding_transcript | F57F5.4a.1 | ||||||||
| F57F5.4b.1 | |||||||||
| Other_sequence (31) | |||||||||
| Associated_feature | WBsf653178 | ||||||||
| WBsf653179 | |||||||||
| WBsf653180 | |||||||||
| WBsf1001503 | |||||||||
| WBsf015161 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027904 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00015899 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048886 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001481 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1020963 | ||||||||
| Expr1030032 | |||||||||
| Expr1152631 | |||||||||
| Expr2009234 | |||||||||
| Expr2027471 | |||||||||
| Drives_construct | WBCnstr00037751 | ||||||||
| Construct_product | WBCnstr00037751 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (147) | |||||||||
| Interaction (34) | |||||||||
| Map_info | Map | V | Position | 3.57552 | Error | 0.003953 | |||
| Positive | Positive_clone | F57F5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4340 | |||||||
| 4586 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00011866 | ||||||||
| WBPaper00018551 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Sequence connection from [Moorthy S, Chen LS, Bennett V], [krb 020618] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
