WormBase Tree Display for Gene: WBGene00000099
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WBGene00000099 | SMap | S_parent | Sequence | B0207 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | air | ||||||
Allele (19) | |||||||
Legacy_information | [Hodgkin JA] e2631 hermaphrodites are long, uncoordinated and sterile, usually with a conspicuous constriction in the mid-region of the body. Males grow poorly, male tail very abnormal, ME0. | ||||||
[McDowall JS] Sterile adult | |||||||
[C.elegansII] h289 : sterile adult (gonad tumorous mass). OA3: h408, h437, h812 (sterile adults). Cloned: partial cosmid rescue (C32E7); rescued to Mel. [KR] | |||||||
[Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. cytokinesis defects | |||||||
Strain (8) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (65) | |||||||
Ortholog (46) | |||||||
Paralog | WBGene00000098 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | air-2 encodes an aurora/Ipl1-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 i modified in vitro by the GEI-17 E3 SUMO ligase; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies. | Paper_evidence (12) | ||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson1843 | |||||||
WBPerson363 | |||||||
WBPerson567 | |||||||
Date_last_updated | 10 Jun 2015 00:00:00 | ||||||
Automated_description | Enables ATPase binding activity; kinesin binding activity; and protein kinase activity. Involved in several processes, including chromosome condensation; regulation of actomyosin contractile ring contraction; and spindle midzone assembly. Located in condensed nuclear chromosome and spindle midzone. Expressed in oocyte and sperm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human AURKB (aurora kinase B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||
DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||
DOID:3008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||
DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393) | ||||
DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||
DOID:0070183 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11391) | ||||
DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||
DOID:8634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11390,HGNC:11393) | ||||
DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||
DOID:363 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11393) | ||||
Molecular_info | Corresponding_CDS | B0207.4 | |||||
Corresponding_transcript | B0207.4.1 | ||||||
B0207.4.2 | |||||||
Other_sequence (54) | |||||||
Associated_feature | WBsf217728 | ||||||
WBsf217729 | |||||||
Experimental_info | RNAi_result (63) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00037734 | ||||||
Construct_product | WBCnstr00000897 | ||||||
WBCnstr00005318 | |||||||
WBCnstr00005560 | |||||||
WBCnstr00014917 | |||||||
WBCnstr00017655 | |||||||
WBCnstr00021506 | |||||||
WBCnstr00037734 | |||||||
Antibody | WBAntibody00000198 | ||||||
WBAntibody00000511 | |||||||
WBAntibody00001492 | |||||||
WBAntibody00002053 | |||||||
WBAntibody00002354 | |||||||
WBAntibody00002454 | |||||||
WBAntibody00002607 | |||||||
WBAntibody00002722 | |||||||
WBAntibody00002782 | |||||||
Microarray_results (21) | |||||||
Expression_cluster (167) | |||||||
Interaction (256) | |||||||
Map_info | Map | I | Position | 0.482005 | Error | 0.002155 | |
Well_ordered | |||||||
Positive | Positive_clone | B0207 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
C32E7 | |||||||
Negative | Outside_rearr | hDf29 | |||||
Negative_clone | C03E6 | ||||||
C04F1 | |||||||
C07F10 | |||||||
C30B6 | |||||||
C53A11 | |||||||
Mapping_data | 2_point | 5225 | |||||
5226 | |||||||
Multi_point | 3520 | ||||||
3865 | |||||||
4380 | |||||||
4601 | |||||||
Pos_neg_data (12) | |||||||
Reference (120) | |||||||
Remark | [McDowall JS] Extrachromosomal array containing single cosmid generated, then manipulated genetically. Partial rescue: normally sterile adult with tumorous mass, develops to tumorless egg-laying adult, eggs do not develop or hatch. | ||||||
testing swap around with sup-40, from 0.435 to 0.575 | |||||||
same as cyk-6 according to cgc4544 and email 114. | |||||||
same as air-2 according to cgc4544 and email 114. | |||||||
old_name cyk-6 becomes new_name air-2 from [Woollard A, Hodgkin JA, Schumacher J]. | |||||||
old_names let-603 and stu-7 had previously been identitifed with air-2. | |||||||
Method | Gene |