WormBase Tree Display for Gene: WBGene00000200
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| WBGene00000200 | Evidence | Paper_evidence | WBPaper00005843 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K07C5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | arx-2 | Person_evidence | WBPerson633 | |||||
| Sequence_name | K07C5.1 | ||||||||
| Molecular_name | K07C5.1 | ||||||||
| K07C5.1.1 | |||||||||
| CE06111 | |||||||||
| Other_name | arp-2 | Paper_evidence | WBPaper00032282 | ||||||
| CELE_K07C5.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | arx-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | arx | ||||||||
| Allele (40) | |||||||||
| Strain | WBStrain00031928 | ||||||||
| WBStrain00007882 | |||||||||
| WBStrain00007883 | |||||||||
| WBStrain00007878 | |||||||||
| WBStrain00055597 | |||||||||
| WBStrain00055596 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (40) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | arx-2 also called as Arp-2 encodes a subunit of the actin related protein of the conserved Arp2/3 complex, with 60% amino acid similarity with the homologous genes from human (OMIM: 604221); arx-2 is an essential gene as disruption in the expression by RNAi results in embryonic arrest due to ventral enclosure defects during morphogenesis; Arp2/3 depletion results in partial shrinking of the Ea/p apical surfaces and incomplete Ea/p cell internalization; WSP-1 activates Arp2/3 complex and their function in ventral enclosure is cell autonomous; Arp2/3 regulates some Apical Junction components in embryos and adults; Arp2/3 is required during intestinal morphogenesis for regulation of intestinal lumen width in embryos and apical F-actin accumulation during larval and adult growth. Mutations in arx-2 causes PDE axon guidance defects; arx-2 mutants affect PQR growth cone morphology and filopodia formation. | Paper_evidence | WBPaper00005843 | |||||
| WBPaper00035433 | |||||||||
| WBPaper00039779 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 10 Aug 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; embryonic morphogenesis; and epithelial cell migration. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of Arp2/3 protein complex. Expressed in Q cell; anchor cell; apoptotic cell; seam cell; and socket cell. Human ortholog(s) of this gene implicated in colorectal carcinoma. Is an ortholog of human ACTR2 (actin related protein 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:850 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:169) | ||||
| DOID:0080199 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:169) | ||||||
| Molecular_info | Corresponding_CDS | K07C5.1 | |||||||
| Corresponding_transcript | K07C5.1.1 | ||||||||
| Other_sequence (80) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (36) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00037669 | ||||||||
| Construct_product | WBCnstr00018598 | ||||||||
| WBCnstr00037669 | |||||||||
| WBCnstr00039445 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (96) | |||||||||
| Interaction (153) | |||||||||
| Map_info | Map | V | Position | 2.50839 | Error | 0.004465 | |||
| Positive | Positive_clone | K07C5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5007 | |||||||
| 5013 | |||||||||
| 4801 | |||||||||
| 4837 | |||||||||
| 5658 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (32) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
