WormBase Tree Display for Gene: WBGene00000217
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| WBGene00000217 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | R12H7 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | asp-4 | Person_evidence | WBPerson184 | |||||
| Sequence_name | R12H7.2 | ||||||||
| Molecular_name | R12H7.2 | ||||||||
| R12H7.2.1 | |||||||||
| CE03567 | |||||||||
| Other_name | CELE_R12H7.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | asp-4 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | asp | ||||||||
| Allele (49) | |||||||||
| Strain | WBStrain00032719 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (36) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | asp-4 encodes an aspartyl protease homolog that is required, in parallel with ASP-3 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). | Paper_evidence | WBPaper00005513 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Is an ortholog of human CTSD (cathepsin D). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2529) | ||||
| DOID:0110725 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2529) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2529) | ||||||
| Molecular_info | Corresponding_CDS | R12H7.2 | |||||||
| Corresponding_transcript | R12H7.2.1 | ||||||||
| Other_sequence (376) | |||||||||
| Associated_feature | WBsf654513 | ||||||||
| WBsf671185 | |||||||||
| WBsf671186 | |||||||||
| WBsf671187 | |||||||||
| WBsf671188 | |||||||||
| WBsf1007568 | |||||||||
| WBsf1024206 | |||||||||
| WBsf238104 | |||||||||
| WBsf238105 | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern | Expr1023600 | ||||||||
| Expr1030134 | |||||||||
| Expr1155523 | |||||||||
| Expr2009468 | |||||||||
| Expr2027706 | |||||||||
| Drives_construct | WBCnstr00037655 | ||||||||
| Construct_product | WBCnstr00037655 | ||||||||
| Antibody | WBAntibody00003051 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (305) | |||||||||
| Interaction (199) | |||||||||
| Map_info | Map | X | Position | 10.3837 | Error | 0.065478 | |||
| Positive | Positive_clone | R12H7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Sequence connection from [Freedman J] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
