WormBase Tree Display for Gene: WBGene00000388
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WBGene00000388 | SMap | S_parent | Sequence | ZK637 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cdc | ||||||
Allele (25) | |||||||
Strain | WBStrain00002130 | ||||||
WBStrain00001389 | |||||||
WBStrain00031390 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (34) | |||||||
Paralog | WBGene00000386 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00000387 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00000389 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | cdc-25.3 encodes a tyrosine phosphatase that is a member of the cell division cycle 25 (CDC25) family of cell cycle regulators that includes Schizosaccharomyces pombe CDC25 and Drosophila string; cdc-25.3 is one of four cdc-25 genes in C. elegans and while it is known to be expressed in hermaphrodites, the precise function of cdc-25.3 is not yet clear; cdc-25.3 may function redundantly with cdc-25.2 during embryonic development and redundantly with cdc-25.1, cdc-25.2, and emb-29 during meiosis. | Paper_evidence | WBPaper00003164 | |||
WBPaper00011225 | |||||||
WBPaper00017563 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson324 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of G2/MI transition of meiotic cell cycle. Located in nucleus. Expressed in ABa; ABp; and germ line. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive polycystic kidney disease; endometrial hyperplasia; and reproductive organ cancer (multiple). Is an ortholog of human CDC25A (cell division cycle 25A); CDC25B (cell division cycle 25B); and CDC25C (cell division cycle 25C). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1726) | ||
DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1726) | ||||
DOID:0110861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1725) | ||||
DOID:2101 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1726,HGNC:1727) | ||||
DOID:0080365 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1726,HGNC:1727) | ||||
DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1726,HGNC:1727) | ||||
DOID:4362 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1725,HGNC:1727) | ||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1727) | ||||
DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1726,HGNC:1727) | ||||
Molecular_info | Corresponding_CDS | ZK637.11 | |||||
Corresponding_transcript | ZK637.11.1 | ||||||
Other_sequence (13) | |||||||
Associated_feature | WBsf651318 | ||||||
WBsf651319 | |||||||
WBsf993515 | |||||||
WBsf227209 | |||||||
Experimental_info | RNAi_result | WBRNAi00022096 | Inferred_automatically | RNAi_primary | |||
WBRNAi00038381 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059582 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00110768 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059581 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005830 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00000434 | ||||||
WBCnstr00004288 | |||||||
WBCnstr00037578 | |||||||
Construct_product | WBCnstr00000434 | ||||||
WBCnstr00037578 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (186) | |||||||
Interaction (145) | |||||||
Map_info | Map | III | Position | 0.040793 | Error | 0.003949 | |
Positive | Positive_clone | ZK637 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4187 | |||||
4764 | |||||||
5435 | |||||||
5518 | |||||||
Pseudo_map_position | |||||||
Reference (28) | |||||||
Remark | email 16 from wen chen | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |