WormBase Tree Display for Gene: WBGene00000407
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| WBGene00000407 | Evidence | Accession_evidence | EMBL | AF129111 | |||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T27E9 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cdk-5 | Person_evidence | WBPerson346 | |||||
| Sequence_name | T27E9.3 | ||||||||
| Molecular_name | T27E9.3 | ||||||||
| T27E9.3.1 | |||||||||
| CE21213 | |||||||||
| Other_name | CELE_T27E9.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | cdk-5 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdk | ||||||||
| Reference_allele | WBVar00239195 | ||||||||
| Allele (41) | |||||||||
| Strain | WBStrain00031527 | ||||||||
| WBStrain00007494 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (49) | |||||||||
| Ortholog (35) | |||||||||
| Paralog (18) | |||||||||
| Structured_description | Concise_description | cdk-5 encodes a proline-directed protein serine/threonine kinase homologous to cyclin dependent kinase 5 (CDK5); in ventral cord interneurons, CDK-5 activity regulates the subcellular localization of LIN-10 which, in turn, regulates the synaptic localization of the GLR-1 glutamate receptor; cdk-5 also regulates the polarized distribution of neuropeptide-containing dense core vesicles in cholinergic motor neurons; CDK-5 phosphorylates LIN-10 in vitro. | Paper_evidence | WBPaper00040649 | |||||
| WBPaper00030893 | |||||||||
| WBPaper00041192 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 04 Feb 2013 00:00:00 | ||||||||
| Automated_description | Enables protein kinase activity. Involved in several processes, including GABAergic synaptic transmission; regulation of cellular localization; and regulation of synapse organization. Located in axon and synapse. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Is an ortholog of human CDK5 (cyclin dependent kinase 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Aug 2021 00:00:00 | ||||||||
| DOID:0050453 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||||
| Accession_evidence | OMIM | 607432 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Apr 2013 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1774) | |||||
| DOID:0112231 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1774) | ||||||
| Disease_relevance | In humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; studies in the worm show that cdk-5 (orthologous to human CDK5), is a LIS1 pathway component and worms depleted for LIS1 pathway components via RNA interference: NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1, also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals. | Homo sapiens | Curator_confirmed | WBPerson324 | |||||
| Models_disease_in_annotation | WBDOannot00000151 | ||||||||
| WBDOannot00001013 | |||||||||
| Molecular_info | Corresponding_CDS | T27E9.3 | |||||||
| Corresponding_transcript | T27E9.3.1 | ||||||||
| Other_sequence | AF129111 | ||||||||
| Associated_feature | WBsf651579 | ||||||||
| WBsf667584 | |||||||||
| WBsf667585 | |||||||||
| WBsf667586 | |||||||||
| WBsf667587 | |||||||||
| WBsf994897 | |||||||||
| WBsf994898 | |||||||||
| WBsf1016373 | |||||||||
| WBsf227752 | |||||||||
| WBsf227753 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00086131 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00006102 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00111862 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019344 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061488 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076721 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054326 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036039 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9053 | ||||||||
| Expr1020175 | |||||||||
| Expr1030224 | |||||||||
| Expr1157873 | |||||||||
| Expr2009812 | |||||||||
| Expr2028053 | |||||||||
| Drives_construct | WBCnstr00037564 | ||||||||
| Construct_product (15) | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (91) | |||||||||
| Map_info | Map | III | Position | 21.2193 | Error | 0.000237 | |||
| Positive | Positive_clone | T27E9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4197 | |||||||
| Pseudo_map_position | |||||||||
| Reference (48) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
