WormBase Tree Display for Gene: WBGene00000427
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| WBGene00000427 | SMap | S_parent | Sequence | R09F10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ced-13 | Person_evidence | WBPerson261 | |||||
| Sequence_name | R09F10.9 | ||||||||
| Molecular_name | R09F10.9 | ||||||||
| R09F10.9.1 | |||||||||
| CE23911 | |||||||||
| Other_name | cip-1 | ||||||||
| CELE_R09F10.9 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | ced-13 | ||||||||
| DB_info | Database | AceView | gene | XI914 | |||||
| WormQTL | gene | WBGene00000427 | |||||||
| WormFlux | gene | WBGene00000427 | |||||||
| NDB | locus_tag | CELE_R09F10.9 | |||||||
| NCBI | gene | 191625 | |||||||
| RefSeq | protein | NM_077001.2 | |||||||
| TrEMBL | UniProtAcc | Q9TY06 | |||||||
| UniProt_GCRP | UniProtAcc | Q9TY06 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ced | ||||||||
| Allele (14) | |||||||||
| Strain | WBStrain00026470 | ||||||||
| WBStrain00035832 | |||||||||
| WBStrain00007562 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00097389 | ||||||||
| 00097390 | |||||||||
| 00097391 | |||||||||
| Structured_description | Concise_description | ced-13 encodes a 98-residue protein with a single BH3 domain, whoseoverexpression promotes CED-3/4-dependent apoptosis; CED-13 binds theBcl-2 ortholog CED-9, and ced-13 is transcriptionally activated by the p53ortholog CEP-1, and the ced-13 promoter contains several potentialp53-binding sites; ced-13 mutations are mostly indistinguishable fromwild-type, but may enhance the abnormal response to germline irradiationseen for egl-1 mutations; peptides containing the BH3 domains of eitherCED-13 or EGL-1 can dissociate stable CED-4/CED-9 heterotetramers invitro if CED-9 is wild-type, but not if CED-9 has a gain-of-function G169Emutation. | Paper_evidence | WBPaper00024937 | |||||
| WBPaper00026815 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 10 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R09F10.9 | |||||||
| Corresponding_transcript | R09F10.9.1 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00051642 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern | Expr3458 | ||||||||
| Expr1018838 | |||||||||
| Expr1155314 | |||||||||
| Expr2009844 | |||||||||
| Expr2028084 | |||||||||
| Drives_construct | WBCnstr00037549 | ||||||||
| Construct_product | WBCnstr00037549 | ||||||||
| Microarray_results (12) | |||||||||
| Expression_cluster (57) | |||||||||
| Interaction (21) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000092 | |||||||||
| Map_info | Map | X | Position | -0.185898 | Error | 0.004091 | |||
| Positive | Positive_clone | R09F10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4200 | |||||||
| 4975 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (58) | |||||||||
| Picture | WBPicture0000013091 | ||||||||
| Remark | This gene used to be called cip-1, renamed according to [Shaham S, Conradt B]. [krb 020614] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
