WormBase Tree Display for Gene: WBGene00000436
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| WBGene00000436 | SMap | S_parent | Sequence | F33D11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ceh-12 | Person_evidence | WBPerson83 | |||||
| Sequence_name | F33D11.4 | ||||||||
| Molecular_name | F33D11.4a | ||||||||
| F33D11.4a.1 | |||||||||
| CE09894 | |||||||||
| F33D11.4b | |||||||||
| CE51241 | |||||||||
| F33D11.4b.1 | |||||||||
| Other_name | CELE_F33D11.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | ceh-12 | ||||||||
| DB_info | Database | AceView | gene | 1G419 | |||||
| WormQTL | gene | WBGene00000436 | |||||||
| WormFlux | gene | WBGene00000436 | |||||||
| NDB | locus_tag | CELE_F33D11.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000436|UniProtKB=P17487 | |||||||
| family | PTHR24335 | ||||||||
| NCBI | gene | 172255 | |||||||
| RefSeq | protein | NM_059292.2 | |||||||
| NM_001322676.1 | |||||||||
| TrEMBL | UniProtAcc | A0A131MAP5 | |||||||
| UniProt_GCRP | UniProtAcc | A0A131MAP5 | |||||||
| OMIM | gene | 142994 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ceh | ||||||||
| Allele (22) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes homeoprotein. [Schaller et al. 1990] | ||||||||
| Strain | WBStrain00036233 | ||||||||
| WBStrain00036269 | |||||||||
| WBStrain00049285 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00045215 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00011069 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Structured_description | Concise_description | ceh-12 encodes a homeobox protein orthologous to human HLXB9 (OMIM:142994, mutated in Currarino syndrome) that is required for normal synaptic inputs to motor neurons VA2-VA10 (sisters to VB3-VB11); ceh-12 is expressed in VB motor neurons, but repressed in their VA siblings by UNC-4 and UNC-37; unc-4 or unc-37 mutants show ectopic CEH-12 expression in VA neurons, which is both necessary and sufficient to induce VA neurons to form gap junctions with normally VB-specific interneurons; ceh-12 mutations have no grossly obvious phenotype, and have no effect on del-1 or acr-5 repression in VB neurons, but do suppress the backward movement defect of unc-4 mutants, and do derepress vab-7 (normally restricted to DB and VC motor neurons); CEH-12, like other HLXB9 orthologs, has an N-terminal eh1 domain that may interact with UNC-37/Groucho, and that may indicate CEH-12 to be a transcriptional repressor. | Paper_evidence | WBPaper00029115 | |||||
| WBPaper00030905 | |||||||||
| WBPaper00030906 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Aug 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in central nervous system development and neuron projection morphogenesis. Predicted to be located in nucleus. Expressed in VB neuron; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in Currarino syndrome. Is an ortholog of human MNX1 (motor neuron and pancreas homeobox 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111546 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4979) | ||||
| Molecular_info | Corresponding_CDS | F33D11.4a | |||||||
| F33D11.4b | |||||||||
| Corresponding_transcript | F33D11.4a.1 | ||||||||
| F33D11.4b.1 | |||||||||
| Other_sequence | Acan_isotig21153 | ||||||||
| Oden_isotig26679 | |||||||||
| JI178214.1 | |||||||||
| Associated_feature | WBsf983781 | ||||||||
| WBsf217715 | |||||||||
| Transcription_factor | WBTranscriptionFactor000305 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00046195 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00093985 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031714 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00093994 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4784 | ||||||||
| Expr7535 | |||||||||
| Expr15562 | |||||||||
| Expr1028012 | |||||||||
| Expr1150083 | |||||||||
| Expr1170021 | |||||||||
| Expr2009859 | |||||||||
| Expr2028099 | |||||||||
| Drives_construct | WBCnstr00005007 | ||||||||
| WBCnstr00005008 | |||||||||
| WBCnstr00005009 | |||||||||
| WBCnstr00009553 | |||||||||
| WBCnstr00012680 | |||||||||
| WBCnstr00014603 | |||||||||
| WBCnstr00037541 | |||||||||
| WBCnstr00042408 | |||||||||
| WBCnstr00042430 | |||||||||
| Construct_product | WBCnstr00037541 | ||||||||
| WBCnstr00042408 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (55) | |||||||||
| Interaction (57) | |||||||||
| Map_info | Map | I | Position | 0.469941 | Error | 0.000381 | |||
| Positive | Positive_clone | DDDG7! | |||||||
| F33D11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4575 | |||||||
| 4926 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
