WormBase Tree Display for Gene: WBGene00000518
expand all nodes | collapse all nodes | view schema
| WBGene00000518 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_III | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | ckk-1 | Person_evidence | WBPerson321 | |||||
| Sequence_name | C05H8.1 | ||||||||
| Molecular_name | C05H8.1a | ||||||||
| C05H8.1a.1 | |||||||||
| CE33594 | |||||||||
| C05H8.1b | |||||||||
| CE37082 | |||||||||
| C05H8.1b.1 | |||||||||
| Other_name | CELE_C05H8.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | ckk-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 29 Nov 2004 18:16:09 | WBPerson2970 | Event | Acquires_merge | WBGene00015498 | ||||
| Acquires_merge | WBGene00015498 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ckk | ||||||||
| Allele (264) | |||||||||
| Strain | WBStrain00035983 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (39) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | ckk-1 encodes a serine/threonine protein kinase that is the C. elegans calcium and calmodulin-dependent protein kinase kinase (CaM-KK) ortholog; ckk-1 activity is required for CRE-dependent transcription in neurons; when expressed in vitro, CKK-1 is capable of stimulating the kinase activity of a downstream kinase, either C. elegans CMK-1 or recombinant mouse CaM-KIV, in a Ca2+/calmodulin-dependent manner; when expressed in COS-7 cells, CKK-1 and CMK-1 positively regulate the transcriptional activity of endogenous CREB. | Paper_evidence | WBPaper00003625 | |||||
| WBPaper00005563 | |||||||||
| WBPaper00012769 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 07 Aug 2008 00:00:00 | ||||||||
| Automated_description | Enables calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in CAMKK-AMPK signaling cascade. Located in cytoplasm and nucleus. Expressed in head neurons; tail neurons; and vulval muscle. Human ortholog(s) of this gene implicated in high grade glioma. Is an ortholog of human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1470) | ||||
| Molecular_info | Corresponding_CDS | C05H8.1a | |||||||
| C05H8.1b | |||||||||
| Corresponding_CDS_history | C05H8.1:wp97 | ||||||||
| C05H8.1:wp127 | |||||||||
| Corresponding_transcript | C05H8.1a.1 | ||||||||
| C05H8.1b.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (23) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00005951 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00010251 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039805 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010252 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005133 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028241 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039804 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11938 | ||||||||
| Expr1027134 | |||||||||
| Expr1030308 | |||||||||
| Expr1143886 | |||||||||
| Expr2010033 | |||||||||
| Expr2028274 | |||||||||
| Drives_construct | WBCnstr00019740 | ||||||||
| WBCnstr00037480 | |||||||||
| Construct_product | WBCnstr00037480 | ||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (36) | |||||||||
| Map_info | Map | III | Position | -1.46504 | Error | 0.001181 | |||
| Positive | Positive_clone | C05H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | Sequence connection from [Kimura Y] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
