WormBase Tree Display for Gene: WBGene00000527
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| WBGene00000527 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cle-1 | Person_evidence | WBPerson345 | |||||
| Sequence_name | C36B1.1 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | cpg-10 | Paper_evidence | WBPaper00053350 | ||||||
| CELE_C36B1.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | cle-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cle | ||||||||
| Allele (206) | |||||||||
| Strain | WBStrain00036123 | ||||||||
| WBStrain00036159 | |||||||||
| WBStrain00036191 | |||||||||
| WBStrain00005031 | |||||||||
| WBStrain00050770 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (36) | |||||||||
| Paralog (162) | |||||||||
| Structured_description | Concise_description | cle-1 encodes the only vertebrate type XV/XVIII collagen homolog in C. elegans and generates multiple developmentally regulated protein isoforms via alternative splicing; cle-1 is required for neuron migrations, including the migration of the HSN, ALM and AVM neurons, axon guidance of the sensory and motor neurons, distal tip cell migration, and for proper morphogenesis of the mail tail; cle-1 is also involved in synaptogenesis and cholinergic synaptic transmission; RNA interference of cle-1 causes significant embryonic and larval lethality; cle-1 is strongly expressed in neurons and at the junctions between body wall muscles and localizes to basement membranes. | Paper_evidence | WBPaper00004615 | |||||
| WBPaper00005871 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 03 Jan 2011 00:00:00 | ||||||||
| Automated_description | Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including cholinergic synaptic transmission; generation of neurons; and inductive cell migration. Located in basement membrane and cell junction. Expressed in several structures, including basal lamina; head mesodermal cell; neurons; smooth muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Is an ortholog of human COL15A1 (collagen type XV alpha 1 chain) and COL18A1 (collagen type XVIII alpha 1 chain). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1405 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2195) | ||||
| EFO:MONDO:0800166 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2195) | ||||||
| Molecular_info | Corresponding_CDS | C36B1.1a | |||||||
| C36B1.1b | |||||||||
| C36B1.1c | |||||||||
| C36B1.1d | |||||||||
| Corresponding_CDS_history | C36B1.1:wp53 | ||||||||
| C36B1.1:wp68 | |||||||||
| C36B1.1a:wp128 | |||||||||
| C36B1.1d:wp128 | |||||||||
| C36B1.1d:wp130 | |||||||||
| Corresponding_transcript | C36B1.1a.1 | ||||||||
| C36B1.1b.1 | |||||||||
| C36B1.1c.1 | |||||||||
| C36B1.1d.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00106825 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003100 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042032 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003096 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042034 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003641 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042033 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001257 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027899 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110300 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr859 | ||||||||
| Expr860 | |||||||||
| Expr2567 | |||||||||
| Expr1020118 | |||||||||
| Expr1030314 | |||||||||
| Expr1146029 | |||||||||
| Expr2010047 | |||||||||
| Expr2028288 | |||||||||
| Drives_construct | WBCnstr00013384 | ||||||||
| WBCnstr00037472 | |||||||||
| Construct_product | WBCnstr00037472 | ||||||||
| Antibody | WBAntibody00000353 | ||||||||
| Microarray_results (51) | |||||||||
| Expression_cluster (237) | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | I | Position | 3.03569 | Error | 0.003514 | |||
| Positive | Positive_clone | C36B1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4223 | |||||||
| Pseudo_map_position | |||||||||
| Reference (39) | |||||||||
| Remark | Sequence connections from [Crew JR, Kramer JM] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
