WormBase Tree Display for Gene: WBGene00001016
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| WBGene00001016 | Evidence | Person_evidence | WBPerson338 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F43G6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | dna-2 | Person_evidence | WBPerson338 | |||||
| Sequence_name | F43G6.1 | ||||||||
| Molecular_name | F43G6.1 | ||||||||
| F43G6.1.1 | |||||||||
| CE23725 | |||||||||
| Other_name | CELE_F43G6.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | dna-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dna | ||||||||
| Allele (72) | |||||||||
| Strain | WBStrain00028635 | ||||||||
| WBStrain00055425 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (39) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00001258 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00016566 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004880 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00007329 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00008099 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00014208 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00010989 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00014965 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016565 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | dna-2 encodes the C. elegans ortholog of the yeast and vertebrate Dna2 replication helicases; by homology, DNA-2 is predicted to function as an endonuclease and an ATP-dependent helicase that is involved in DNA replication and repair; in C. elegans, DNA-2 activity is required maternally and zygotically to maintain normal rates of cell division and for proper germ-line, embryonic, and larval development; DNA-2 activity is temperature-sensitive: animals lacking DNA-2 at 16 degrees Celsius (C) are less severely affected than those at 20 or 25 degrees C; in the hermaphrodite gonad, DNA-2 localizes to nuclei of germ cells and developing oocytes, and expression continues in embryos up to the comma stage; DNA-2 then reappears at the L3 larval stage, and in L3 and L4 larvae is visible in the proliferating somatic cells of the uterus and spermatheca. | Paper_evidence | WBPaper00005745 | |||||
| WBPaper00006262 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Mar 2005 00:00:00 | ||||||||
| Automated_description | Enables 5'-3' DNA helicase activity; single-stranded DNA endodeoxyribonuclease activity; and single-stranded DNA helicase activity. Involved in DNA metabolic process. Located in nucleus. Expressed in gonad; oocyte; spermatheca; and uterus. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; and isolated growth hormone deficiency type IA. Is an ortholog of human DNA2 (DNA replication helicase/nuclease 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111519 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2939) | ||||
| DOID:699 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2939) | ||||||
| DOID:0070009 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2939) | ||||||
| DOID:0060873 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2939) | ||||||
| Molecular_info | Corresponding_CDS | F43G6.1 | |||||||
| Corresponding_CDS_history | F43G6.1a:wp252 | ||||||||
| Corresponding_transcript | F43G6.1.1 | ||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf644723 | ||||||||
| WBsf976362 | |||||||||
| WBsf976363 | |||||||||
| WBsf976364 | |||||||||
| WBsf976365 | |||||||||
| WBsf989891 | |||||||||
| WBsf989892 | |||||||||
| WBsf1013311 | |||||||||
| WBsf222194 | |||||||||
| WBsf222195 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00078457 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00014885 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047208 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014887 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075529 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007731 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2568 | ||||||||
| Expr2569 | |||||||||
| Expr1022435 | |||||||||
| Expr1030630 | |||||||||
| Expr1151065 | |||||||||
| Expr2010977 | |||||||||
| Expr2029215 | |||||||||
| Drives_construct | WBCnstr00000315 | ||||||||
| WBCnstr00010856 | |||||||||
| WBCnstr00037142 | |||||||||
| Construct_product | WBCnstr00037142 | ||||||||
| Antibody | WBAntibody00000607 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (157) | |||||||||
| Interaction (64) | |||||||||
| Map_info | Map | II | Position | 4.048 | Error | 0.003175 | |||
| Positive | Positive_clone | F43G6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
