WormBase Tree Display for Gene: WBGene00001053
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| WBGene00001053 | Evidence | Person_evidence | WBPerson260 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K09G1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | dop-2 | Person_evidence | WBPerson260 | |||||
| Sequence_name | K09G1.4 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | dop-2L | Accession_evidence | EMBL | AB125701 | |||||
| CELE_K09G1.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | dop-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dop | ||||||||
| Allele (100) | |||||||||
| Strain | WBStrain00026373 | ||||||||
| WBStrain00026375 | |||||||||
| WBStrain00026377 | |||||||||
| WBStrain00026379 | |||||||||
| WBStrain00034690 | |||||||||
| WBStrain00034692 | |||||||||
| WBStrain00034693 | |||||||||
| WBStrain00004915 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (53) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | dop-2 is orthologous to the human gene DOPAMINE RECEPTOR D2 (DRD2; OMIM:126450), which when mutated leads to myoclonus-dystonia syndrome. | Curator_confirmed | WBPerson1823 | |||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including cellular response to organonitrogen compound; male mating behavior; and regulation of locomotion involved in locomotory behavior. Predicted to be located in dendrite. Expressed in GLR; male-specific anatomical entity; and neurons. Used to study Parkinson's disease and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; end stage renal disease; essential tremor 1; and type 2 diabetes mellitus. Is an ortholog of human DRD3 (dopamine receptor D3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041253 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Nov 2013 00:00:00 | ||||||||
| DOID:0050742 | Homo sapiens | Paper_evidence | WBPaper00041959 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 May 2019 00:00:00 | ||||||||
| Potential_model (16) | |||||||||
| Disease_relevance | In elegans, alpha-synuclein (alpha-syn) toxicity, implicated in Parkinson''s disease and other synucleinopathies, is modeled by expressing it from the dopamine transporter (dat-1) gene promotor in transgenic GFP worms, resulting in an age-dependent progressive loss of dopaminergic neurons; using this system, it was seen that the knock-down of specific candidate genes in elegans, that interact with catp-6/ATP13A2, resulted in significant enhancement of alpha-syn-induced dopaminergic neurodegeneration; these catp-6/ATP13A2 interactors include the elegans ortholog of coagulation factor II (thrombin) receptor (dop-2), AP2 associated kinase 1 (AAK1; sel-5) along with neuropeptide Y receptor Y1 (npr-4), histone deacetylase 6 (hda-6), and YIP1 interacting factor homolog A (yif-1). | Homo sapiens | Paper_evidence | WBPaper00041253 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Nov 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000248 | ||||||||
| Models_disease_asserted | WBDOannot00000688 | ||||||||
| Molecular_info | Corresponding_CDS | K09G1.4a | |||||||
| K09G1.4c | |||||||||
| K09G1.4d | |||||||||
| K09G1.4e | |||||||||
| K09G1.4f | |||||||||
| K09G1.4g | |||||||||
| Corresponding_CDS_history | K09G1.4:wp82 | ||||||||
| K09G1.4:wp113 | |||||||||
| K09G1.4b:wp270 | |||||||||
| Corresponding_transcript | K09G1.4a.1 | ||||||||
| K09G1.4c.1 | |||||||||
| K09G1.4d.1 | |||||||||
| K09G1.4e.1 | |||||||||
| K09G1.4f.1 | |||||||||
| K09G1.4g.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf1000951 | ||||||||
| WBsf1000952 | |||||||||
| WBsf1000953 | |||||||||
| WBsf1020204 | |||||||||
| WBsf232275 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00016938 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00108504 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050456 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2618 | ||||||||
| Expr2709 | |||||||||
| Expr8666 | |||||||||
| Expr12406 | |||||||||
| Expr15334 | |||||||||
| Expr1029157 | |||||||||
| Expr1154163 | |||||||||
| Expr2011027 | |||||||||
| Expr2029264 | |||||||||
| Drives_construct | WBCnstr00001469 | ||||||||
| WBCnstr00010872 | |||||||||
| WBCnstr00013432 | |||||||||
| WBCnstr00020852 | |||||||||
| WBCnstr00037117 | |||||||||
| Construct_product | WBCnstr00010872 | ||||||||
| WBCnstr00037117 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (143) | |||||||||
| Interaction (24) | |||||||||
| Map_info | Map | V | Position | 2.05503 | Error | 0.000659 | |||
| Positive | Positive_clone | K09G1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (77) | |||||||||
| Remark | dop-2 is a D2-subtype dopamine receptor [Hobert O][030401 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
