WormBase Tree Display for Gene: WBGene00001132
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| WBGene00001132 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | alp-1 | Person_evidence | WBPerson910 | |||||
| Sequence_name | T11B7.4 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_T11B7.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | alp-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 16 Jan 2006 17:50:31 | WBPerson2970 | Name_change | CGC_name | alp-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | alp | ||||||||
| Allele (152) | |||||||||
| Strain | WBStrain00035455 | ||||||||
| WBStrain00035457 | |||||||||
| WBStrain00031648 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (60) | |||||||||
| Paralog | WBGene00014262 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | alp-1 encodes the C. elegans ortholog of the ALP (alpha-actininassociated LIM protein)-Enigma family of proteins that are found at sites of actin filament anchorage, such as the muscle Z disk; in C. elegans, alp-1 is required for maintenance of actin filament organization and for stabilizing muscle contraction; ALP-1 co-localizes with alpha-actinin at body wall muscle dense bodies, and its localization is dependent upon alpha-actinin. | Paper_evidence | WBPaper00032968 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 Jul 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Involved in determination of adult lifespan and pharyngeal pumping. Located in several cellular components, including actin filament bundle; basal part of cell; and striated muscle dense body. Expressed in body wall musculature; hypodermis; marginal cell; and pharyngeal muscle cell. Used to study cardiomyopathy and myopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1C; distal myopathy; myofibrillar myopathy 4; and myotonic dystrophy type 1. Is an ortholog of human PDLIM5 (PDZ and LIM domain 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:423 | Homo sapiens | Paper_evidence | WBPaper00032968 | ||||
| Accession_evidence | OMIM | 609452 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Oct 2018 00:00:00 | ||||||||
| DOID:0050700 | Homo sapiens | Paper_evidence | WBPaper00032968 | ||||||
| Accession_evidence | OMIM | 601493 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Oct 2018 00:00:00 | ||||||||
| Potential_model | DOID:11720 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15710) | |||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15710) | ||||||
| DOID:0080095 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15710) | ||||||
| DOID:0110423 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15710) | ||||||
| DOID:11722 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15710) | ||||||
| Disease_relevance | Muscular dystrophies are a group of hereditary muscle diseases characterized by progressive muscle weakness; several proteins including the ALP (alpha-actinin-associated LIM protein)-Enigma proteins, a group of evolutionarily conserved proteins localized at the Z-disk and other sites of actin filament anchorage, are implicated in myopathies; though alp-1 mutant worms have grossly normal muscle function they show an alteration in action filaments in body wall muscle, exhibiting small actin aggregates at the ends of muscle. | Homo sapiens | Paper_evidence | WBPaper00032968 | |||||
| WBPaper00026945 | |||||||||
| Accession_evidence | OMIM | 601493 | |||||||
| 609452 | |||||||||
| 605906 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Apr 2015 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000283 | ||||||||
| WBDOannot00000319 | |||||||||
| Molecular_info | Corresponding_CDS | T11B7.4a | |||||||
| T11B7.4b | |||||||||
| T11B7.4c | |||||||||
| T11B7.4d | |||||||||
| T11B7.4e | |||||||||
| Corresponding_CDS_history | T11B7.4b:wp112 | ||||||||
| Corresponding_transcript | T11B7.4a.1 | ||||||||
| T11B7.4b.1 | |||||||||
| T11B7.4c.1 | |||||||||
| T11B7.4d.1 | |||||||||
| T11B7.4e.1 | |||||||||
| Other_sequence (68) | |||||||||
| Associated_feature | WBsf660454 | ||||||||
| WBsf660455 | |||||||||
| WBsf660456 | |||||||||
| WBsf716784 | |||||||||
| WBsf228749 | |||||||||
| WBsf228750 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00009156 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00080557 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002262 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00079868 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018585 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001688 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075890 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00035468 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053101 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053102 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram792 | ||||||||
| Expr3919 | |||||||||
| Expr3920 | |||||||||
| Expr6672 | |||||||||
| Expr8651 | |||||||||
| Expr1013432 | |||||||||
| Expr1030722 | |||||||||
| Expr1156707 | |||||||||
| Expr2009313 | |||||||||
| Expr2027549 | |||||||||
| Drives_construct | WBCnstr00001767 | ||||||||
| WBCnstr00001768 | |||||||||
| WBCnstr00003383 | |||||||||
| WBCnstr00037071 | |||||||||
| Construct_product | WBCnstr00001766 | ||||||||
| WBCnstr00001767 | |||||||||
| WBCnstr00001768 | |||||||||
| WBCnstr00016198 | |||||||||
| WBCnstr00037071 | |||||||||
| Antibody | WBAntibody00001942 | ||||||||
| WBAntibody00001943 | |||||||||
| Microarray_results (42) | |||||||||
| Expression_cluster (209) | |||||||||
| Interaction (375) | |||||||||
| Map_info | Positive | Positive_clone | T11B7 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Mapping_data | 2_point | 4247 | |||||||
| 4450 | |||||||||
| 5205 | |||||||||
| 5526 | |||||||||
| 5527 | |||||||||
| Multi_point | 1535 | ||||||||
| 1537 | |||||||||
| 1612 | |||||||||
| 1832 | |||||||||
| 1922 | |||||||||
| 1876 | |||||||||
| Pos_neg_data | 4244 | ||||||||
| 4245 | |||||||||
| 4246 | |||||||||
| 4451 | |||||||||
| 4452 | |||||||||
| 4647 | |||||||||
| 4648 | |||||||||
| 4649 | |||||||||
| 4650 | |||||||||
| 4651 | |||||||||
| Interpolated_map_position | IV | 3.98591 | |||||||
| Reference (29) | |||||||||
| Remark | eat-1 was previously connected to T11B7.4 based on findings described in WBPaper00018820, WBPaper00012350 & WBPaper00017849. It has subsequently been found that these results were incorrect. The correct eat-1 object can be found in WBGene00044731 | Person_evidence | WBPerson910 | ||||||
| Curator_confirmed | WBPerson2970 | ||||||||
| Method | Gene |
