WormBase Tree Display for Gene: WBGene00001178
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| WBGene00001178 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | egl-9 | Person_evidence | WBPerson268 | |||||
| Sequence_name | F22E12.4 | ||||||||
| Molecular_name (17) | |||||||||
| Other_name | CELE_F22E12.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | egl-9 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | egl | ||||||||
| Reference_allele | WBVar00089612 | ||||||||
| Allele (128) | |||||||||
| Legacy_information | n586ts : transient bloating at 25x Type E. ES2 (adult 25x). NA2 (n571 (non-ts)). | ||||||||
| [C.elegansII] n586ts : transient bloating at 25C; variable drug response; resistant to paralysis by toxin from Pseudomonas aeruginosa. ES2 (adult 25C). ME3. OA3: n571 (non-ts), sa307, sa330. [Trent et al. 1983; MT; JT] | |||||||||
| Strain (21) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | egl-9 encodes a proline hydroxylase; EGL-9 functions in a conserved hypoxia-sensing pathway to negatively regulate HIF-1 (hypoxia inducible factor) by hydroxylating prolyl HIF-1 residues; EGL-9 activity is negatively regulated by its physical association with CYSL-1, a protein with similarity to cysteine synthases that acts to transduce information about the environmental O2 levels through H2S (hydrogen sulfide) signaling. | Paper_evidence | WBPaper00000635 | |||||
| WBPaper00003860 | |||||||||
| WBPaper00004898 | |||||||||
| WBPaper00012867 | |||||||||
| WBPaper00040881 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Apr 2012 00:00:00 | ||||||||
| Automated_description | Enables peptidyl-proline 4-dioxygenase activity. Involved in regulation of protein localization and response to hypoxia. Located in dendrite and nucleus. Expressed in ventral nerve cord and vulval precursor cell. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma and familial erythrocytosis 3. Is an ortholog of human EGLN1 (egl-9 family hypoxia inducible factor 1) and EGLN2 (egl-9 family hypoxia inducible factor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14661) | ||||
| DOID:0080338 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1232) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1232,HGNC:14660,HGNC:14661) | ||||||
| DOID:8432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1232) | ||||||
| Molecular_info | Corresponding_CDS | F22E12.4a | |||||||
| F22E12.4b | |||||||||
| F22E12.4c | |||||||||
| F22E12.4d | |||||||||
| F22E12.4e | |||||||||
| Corresponding_CDS_history | F22E12.4:wp51 | ||||||||
| F22E12.4:wp82 | |||||||||
| Corresponding_transcript | F22E12.4a.1 | ||||||||
| F22E12.4b.1 | |||||||||
| F22E12.4b.2 | |||||||||
| F22E12.4b.3 | |||||||||
| F22E12.4c.1 | |||||||||
| F22E12.4d.1 | |||||||||
| F22E12.4e.1 | |||||||||
| Other_sequence (35) | |||||||||
| Associated_feature (30) | |||||||||
| Transcription_factor | WBTranscriptionFactor000599 | ||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr9927 | ||||||||
| Expr14526 | |||||||||
| Expr1022645 | |||||||||
| Expr1030754 | |||||||||
| Expr1149253 | |||||||||
| Expr2011231 | |||||||||
| Expr2029467 | |||||||||
| Drives_construct | WBCnstr00005850 | ||||||||
| WBCnstr00006369 | |||||||||
| WBCnstr00006370 | |||||||||
| WBCnstr00006371 | |||||||||
| WBCnstr00006441 | |||||||||
| WBCnstr00019096 | |||||||||
| WBCnstr00019097 | |||||||||
| WBCnstr00019098 | |||||||||
| WBCnstr00037047 | |||||||||
| Construct_product (21) | |||||||||
| Regulate_expr_cluster | WBPaper00054872:egl-9(sa307)_downregulated | ||||||||
| WBPaper00054872:egl-9(sa307)_upregulated | |||||||||
| WBPaper00064602:egl-9(sa307)_downregulated | |||||||||
| WBPaper00064602:egl-9(sa307)_upregulated | |||||||||
| Microarray_results (48) | |||||||||
| Expression_cluster (133) | |||||||||
| Interaction (236) | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000054 | |||||||||
| Map_info | Map | V | Position | 2.5669 | Error | 0.001344 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F22E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 719 | |||||||
| Multi_point | 614 | ||||||||
| 3785 | |||||||||
| 3786 | |||||||||
| 3787 | |||||||||
| 3788 | |||||||||
| 3789 | |||||||||
| 3972 | |||||||||
| 5046 | |||||||||
| 5081 | |||||||||
| Pos_neg_data | 10605 | ||||||||
| Landmark_gene | |||||||||
| Reference (111) | |||||||||
| Method | Gene |
