eif-3.k encodes the C. elegans ortholog of eukaryotic translation initiation factor 3 subunit k; by homology, EIF-3.K is predicted to function as part of the eIF3 translation initiation complex; in C. elegans eif-3.k activity is also required cell autonomously for positive regulation of ced-3-mediated apoptosis; EIF-3.K is expressed ubiquitously in embryos and larvae and is localized to the cytoplasm.
Predicted to enable RNA binding activity and ribosome binding activity. Predicted to contribute to translation initiation factor activity. Involved in positive regulation of apoptotic process. Located in cytoplasm. Expressed in several structures, including embryonic cell and germ line. Is an ortholog of human EIF3K (eukaryotic translation initiation factor 3 subunit K).
The capital letters are used here to distinguish the different eIF3 subunit genes. This roughly agrees with worm gene nomenclature and it makes clear the orthologies for these universal factors (eif-3B corresponding to eIF3b, and so on), in the unified eIF3 nomenclature proposed by Browning KS et al (2001)[JAH][030106 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.