WormBase Tree Display for Gene: WBGene00001236

WBGene00001236 SMap: S_parent: Sequence: Y82E9BR
  Identity: Version: 1
    Name: CGC_name: elc-1 Person_evidence: WBPerson322
      Sequence_name: Y82E9BR.15
      Molecular_name: Y82E9BR.15
        Y82E9BR.15.1
        CE27039
      Other_name: CELE_Y82E9BR.15 Accession_evidence: NDB BX284603
      Public_name: elc-1
    DB_info: Database: AceView gene 3C506
        WormQTL gene WBGene00001236
        WormFlux gene WBGene00001236
        NDB locus_tag CELE_Y82E9BR.15
        Panther gene CAEEL|WormBase=WBGene00001236|UniProtKB=Q9BKS1
          family PTHR20648
        NCBI gene 190775
        RefSeq protein NM_001393280.1
        TREEFAM TREEFAM_ID TF300233
        TrEMBL UniProtAcc Q9BKS1
        UniProt_GCRP UniProtAcc Q9BKS1
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: elc
    Allele (73)
    RNASeq_FPKM (74)
    GO_annotation (20)
    Contained_in_operon: CEOP3061
    Ortholog (41)
    Paralog: WBGene00077680 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001237 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: elc-1 encodes an ortholog of mammalian elongin C that appears to be required for proteolysis of germ plasm components (ZF1-containing proteins) in somatic cells, and for regulation of the cell cycle by CUL-2; elongin C forms a complex with (and positively regulates) elongin A, the active subunit of RNA polymerase II elongation factor SIII, and also binds to the von Hippel-Lindau (VHL) tumor suppressor; in yeast, elongin C also interacts with stress response proteins. Paper_evidence: WBPaper00010163
            WBPaper00010226
            WBPaper00012763
            WBPaper00012803
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables protein domain specific binding activity and protein-macromolecule adaptor activity. Involved in anterior/posterior axis specification, embryo; positive regulation of metaphase/anaphase transition of meiotic cell cycle; and sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation. Part of Cul2-RING ubiquitin ligase complex. Expressed in hypodermis; pharynx; and vulval muscle. Is an ortholog of human ELOC (elongin C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y82E9BR.15
    Corresponding_transcript: Y82E9BR.15.1
    Other_sequence (67)
    Associated_feature: WBsf226209
      WBsf226210
    Transcription_factor: WBTranscriptionFactor000546
  Experimental_info: RNAi_result (26)
    Expr_pattern: Expr12455
      Expr15111
      Expr1017932
      Expr1030784
      Expr1161996
      Expr2011271
      Expr2029507
    Drives_construct: WBCnstr00021133
      WBCnstr00042009
    Construct_product: WBCnstr00021133
    Antibody: WBAntibody00002165
    Microarray_results (17)
    Expression_cluster (86)
    Interaction (96)
  Map_info: Map: III Position: -21.8617 Error: 0.01934
    Positive: Positive_clone: Y82E9BR Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene