WormBase Tree Display for Gene: WBGene00001509
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| WBGene00001509 | SMap | S_parent | Sequence | ZK1248 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | fzo-1 | |||||||
| Sequence_name | ZK1248.14 | ||||||||
| Molecular_name | ZK1248.14 | ||||||||
| ZK1248.14.1 | |||||||||
| CE02898 | |||||||||
| Other_name | CELE_ZK1248.14 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | fzo-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fzo | ||||||||
| Allele (33) | |||||||||
| Strain | WBStrain00001227 | ||||||||
| WBStrain00005194 | |||||||||
| WBStrain00047166 | |||||||||
| Component_of_genotype | WBGenotype00000133 | ||||||||
| WBGenotype00000135 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP2224 | ||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | fzo-1 encodes a GTPase orthologous to MFN1(Mitofusin)/FZO1, a conserved mitochondrial transmembrane protein essential for mitochondrial fusion; in C. elegans, fzo-1 is also required for mitochondrial fusion and organization and accordingly, is essential for reproduction, embryonic development, and normal growth rates. | Paper_evidence | WBPaper00031376 | |||||
| WBPaper00032123 | |||||||||
| WBPaper00032231 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Aug 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activity. Involved in mitochondrial fusion. Predicted to be located in mitochondrial outer membrane. Expressed in tail. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Charcot-Marie-Tooth disease (multiple); multiple symmetric lipomatosis; and primary pulmonary hypertension. Is an ortholog of human MFN2 (mitofusin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111557 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877) | ||||
| DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877,HGNC:18262) | ||||||
| DOID:10595 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877) | ||||||
| DOID:0080068 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877) | ||||||
| DOID:14557 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877,HGNC:18262) | ||||||
| DOID:14116 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877) | ||||||
| DOID:0110155 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877) | ||||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16877) | ||||||
| Molecular_info | Corresponding_CDS | ZK1248.14 | |||||||
| Corresponding_transcript | ZK1248.14.1 | ||||||||
| Other_sequence (38) | |||||||||
| Associated_feature | WBsf650096 | ||||||||
| WBsf223106 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Chronogram958 | ||||||||
| Expr7194 | |||||||||
| Expr1025639 | |||||||||
| Expr1030906 | |||||||||
| Expr1162603 | |||||||||
| Expr2011926 | |||||||||
| Expr2030163 | |||||||||
| Drives_construct | WBCnstr00002120 | ||||||||
| WBCnstr00036900 | |||||||||
| Construct_product | WBCnstr00005421 | ||||||||
| WBCnstr00005822 | |||||||||
| WBCnstr00005823 | |||||||||
| WBCnstr00005836 | |||||||||
| WBCnstr00036900 | |||||||||
| Regulate_expr_cluster | WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (80) | |||||||||
| Interaction (84) | |||||||||
| Map_info | Map | II | Position | -0.873144 | Error | 0.005225 | |||
| Positive | Positive_clone | ZK1248 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4278 | |||||||
| 5611 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (56) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
