WormBase Tree Display for Gene: WBGene00001512
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| WBGene00001512 | SMap | S_parent | Sequence | ZC482 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gab-1 | Person_evidence | WBPerson134 | |||||
| Sequence_name | ZC482.1 | ||||||||
| Molecular_name | ZC482.1 | ||||||||
| ZC482.1.1 | |||||||||
| CE33742 | |||||||||
| Other_name | gbr-1 | Person_evidence | WBPerson6973 | ||||||
| Author_evidence | Feng X-P | ||||||||
| GABAR/1 | |||||||||
| CELE_ZC482.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | gab-1 | ||||||||
| DB_info | Database | AceView | gene | 3N862 | |||||
| WormQTL | gene | WBGene00001512 | |||||||
| WormFlux | gene | WBGene00001512 | |||||||
| NDB | locus_tag | CELE_ZC482.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001512|UniProtKB=O18276 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 176691 | |||||||
| RefSeq | protein | NM_067260.5 | |||||||
| SwissProt | UniProtAcc | O18276 | |||||||
| UniProt_GCRP | UniProtAcc | O18276 | |||||||
| OMIM | gene | 137163 | |||||||
| 137190 | |||||||||
| 137192 | |||||||||
| 600232 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gab | ||||||||
| Allele (201) | |||||||||
| Legacy_information | [C.elegansII] NMK. Cross-hybridization to GABA receptor probe. [CGC] | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (71) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | gab-1 encodes a gamma-aminobutyric acid (GABA) receptor beta-like subunit with both the neurotransmitter-gated ion-channel ligand binding and transmembrane domains; gab-1 can form a GABA-responsive channel when co-expressed with alpha/gamma type subunits in a heterologous expression system; experiments with gab-1 indicate that GABA receptors are involved in the mechanism of resistance to the widely used broad-spectrum anthelmintic drug Ivermectin. | Paper_evidence | WBPaper00005574 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables GABA-A receptor activity and extracellular ligand-gated monoatomic ion channel activity. Involved in monoatomic ion transport. Predicted to be located in neuron projection and synapse. Predicted to be part of GABA-A receptor complex. Expressed in neurons. Human ortholog(s) of this gene implicated in autistic disorder and epilepsy (multiple). Is an ortholog of human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1) and GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080447 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4083) | ||||
| DOID:0111292 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4084) | ||||||
| DOID:1825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4083) | ||||||
| DOID:0080428 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4081) | ||||||
| DOID:0080471 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4082) | ||||||
| DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4081,HGNC:4082,HGNC:4091) | ||||||
| Molecular_info | Corresponding_CDS | ZC482.1 | |||||||
| Corresponding_CDS_history | ZC482.1:wp59 | ||||||||
| ZC482.1:wp98 | |||||||||
| Corresponding_transcript | ZC482.1.1 | ||||||||
| Other_sequence (20) | |||||||||
| Associated_feature | WBsf651553 | ||||||||
| WBsf994717 | |||||||||
| WBsf994718 | |||||||||
| WBsf994719 | |||||||||
| WBsf1016249 | |||||||||
| WBsf1016250 | |||||||||
| WBsf227682 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00038078 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00058963 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006223 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021726 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9889 | ||||||||
| Expr13161 | |||||||||
| Expr1029016 | |||||||||
| Expr1162398 | |||||||||
| Expr2011929 | |||||||||
| Expr2030166 | |||||||||
| Drives_construct | WBCnstr00009841 | ||||||||
| WBCnstr00036897 | |||||||||
| Construct_product | WBCnstr00036897 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction | WBInteraction000159519 | ||||||||
| WBInteraction000173483 | |||||||||
| WBInteraction000173632 | |||||||||
| WBInteraction000173907 | |||||||||
| WBInteraction000174276 | |||||||||
| WBInteraction000174511 | |||||||||
| WBInteraction000229938 | |||||||||
| WBInteraction000275303 | |||||||||
| WBInteraction000431462 | |||||||||
| Map_info | Map | III | Position | 18.7793 | Error | 0.051577 | |||
| Positive | Positive_clone | ZC482 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZL255 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003954 | ||||||||
| WBPaper00005574 | |||||||||
| WBPaper00006402 | |||||||||
| WBPaper00027250 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00043995 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062289 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
