WormBase Tree Display for Gene: WBGene00001613
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| WBGene00001613 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | glr-2 | Person_evidence | WBPerson42 | |||||
| Sequence_name | B0280.12 | ||||||||
| Molecular_name | B0280.12a | ||||||||
| B0280.12a.1 | |||||||||
| CE31400 | |||||||||
| B0280.12b | |||||||||
| CE33547 | |||||||||
| B0280.12b.1 | |||||||||
| Other_name | CELE_B0280.12 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | glr-2 | ||||||||
| DB_info | Database | AceView | gene | 3I228 | |||||
| WormQTL | gene | WBGene00001613 | |||||||
| WormFlux | gene | WBGene00001613 | |||||||
| NDB | locus_tag | CELE_B0280.12 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001613|UniProtKB=Q10914 | |||||||
| family | PTHR18966 | ||||||||
| NCBI | gene | 175999 | |||||||
| RefSeq | protein | NM_001025943.3 | |||||||
| NM_001025942.4 | |||||||||
| SwissProt | UniProtAcc | Q10914 | |||||||
| UniProt_GCRP | UniProtAcc | Q10914 | |||||||
| OMIM | gene | 138248 | |||||||
| 305915 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | glr | ||||||||
| Allele (129) | |||||||||
| Strain | WBStrain00032499 | ||||||||
| WBStrain00040170 | |||||||||
| WBStrain00040171 | |||||||||
| WBStrain00040797 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (53) | |||||||||
| Paralog | WBGene00001612 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001619 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001617 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001616 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001615 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001614 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001618 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003774 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003775 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012190 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | glr-2 encodes an AMPA (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-2 activity is required for mediating the behavioral response to light nose touch and for regulating the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-2 and GLR-1, a second AMPA-type ionotropic glutamate receptor, can interact to form functional heteromeric channels; GLR-2 is expressed in many neurons, including four of the five pairs of command interneurons that are required for locomotory control. | Paper_evidence | WBPaper00004567 | |||||
| WBPaper00005622 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Sep 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic density membrane. Expressed in DVA; M1 neuron; linker cell; nerve ring; and neurons. Human ortholog(s) of this gene implicated in intellectual disability (multiple) and schizophrenia. Is an ortholog of several human genes including GRIA1 (glutamate ionotropic receptor AMPA type subunit 1); GRIA2 (glutamate ionotropic receptor AMPA type subunit 2); and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4571) | ||||
| DOID:0060823 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4573) | ||||||
| DOID:0081235 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4571) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4574) | ||||||
| Molecular_info | Corresponding_CDS | B0280.12a | |||||||
| B0280.12b | |||||||||
| Corresponding_CDS_history | B0280.12:wp82 | ||||||||
| B0280.12:wp96 | |||||||||
| Corresponding_transcript | B0280.12a.1 | ||||||||
| B0280.12b.1 | |||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf651175 | ||||||||
| WBsf651176 | |||||||||
| WBsf992944 | |||||||||
| WBsf992945 | |||||||||
| WBsf992946 | |||||||||
| WBsf226913 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (16) | |||||||||
| Construct_product | WBCnstr00001341 | ||||||||
| WBCnstr00005578 | |||||||||
| WBCnstr00006174 | |||||||||
| WBCnstr00013154 | |||||||||
| WBCnstr00017838 | |||||||||
| WBCnstr00017839 | |||||||||
| WBCnstr00020619 | |||||||||
| WBCnstr00020815 | |||||||||
| WBCnstr00036825 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (163) | |||||||||
| Interaction (38) | |||||||||
| Map_info | Map | III | Position | -0.78335 | Error | 0.000848 | |||
| Positive | Positive_clone | B0280 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| K04G7 | Person_evidence | WBPerson27 | |||||||
| Mapping_data | Multi_point | 4355 | |||||||
| 4557 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (62) | |||||||||
| Remark | The connected sequence B0280.12 contains a merge of the now-redundant sequence K04G7.2 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
