WormBase Tree Display for Gene: WBGene00001865
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WBGene00001865 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T04A11 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | him-6 | Person_evidence | WBPerson261 | |||||
Sequence_name | T04A11.6 | ||||||||
Molecular_name | T04A11.6 | ||||||||
T04A11.6.1 | |||||||||
CE31724 | |||||||||
Other_name | blm-1 | ||||||||
CELE_T04A11.6 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | him-6 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info (11) | |||||||||
Disease_info | Experimental_model | DOID:2717 | Homo sapiens | Paper_evidence | WBPaper00013454 | ||||
Accession_evidence | OMIM | 210900 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 05 Jun 2017 00:00:00 | ||||||||
Potential_model | DOID:2717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1058) | |||||
Disease_relevance | Mutations in the human BLM gene (a RecQ family DNA helicase) are implicatd in Bloom syndrome, an inherited disorder characterized by short stature, increased sensitivity to sunlight, a greatly increased risk of cancer and infertility; at the cellular level it is characterized by genomic instability, in particular, hyperrecombination between sister chromatids and homologous chromosomes; the C. elegans BLM ortholog, him-6, exhibits DNA-dependent ATPase activity and mutants show an enhanced irradiation sensitivity, a partially defective S-phase checkpoint, and in reduced levels of DNA-damage induced apoptosis. | Homo sapiens | Paper_evidence | WBPaper00013454 | |||||
Accession_evidence | OMIM | 604610 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 05 Jun 2017 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000132 | ||||||||
WBDOannot00000436 | |||||||||
WBDOannot00000437 | |||||||||
WBDOannot00000438 | |||||||||
Molecular_info (5) | |||||||||
Experimental_info | RNAi_result (4) | ||||||||
Expr_pattern | Expr1024637 | ||||||||
Expr1031098 | |||||||||
Expr1155954 | |||||||||
Expr2012431 | |||||||||
Expr2030667 | |||||||||
Drives_construct | WBCnstr00036640 | ||||||||
Construct_product | WBCnstr00036640 | ||||||||
Antibody | WBAntibody00002533 | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (125) | |||||||||
Interaction (123) | |||||||||
Map_info | Map | IV | Position | 5.98937 | Error | 0.002716 | |||
Well_ordered | |||||||||
Positive | Positive_clone | T04A11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 111 | |||||||
112 | |||||||||
113 | |||||||||
5281 | |||||||||
5470 | |||||||||
Pos_neg_data | 5444 | ||||||||
5445 | |||||||||
5446 | |||||||||
5447 | |||||||||
Reference (74) | |||||||||
Remark | Sequence connection from [Wicky C, Muller F] | ||||||||
Method | Gene |