WormBase Tree Display for Gene: WBGene00001995
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| WBGene00001995 | SMap | S_parent | Sequence | K08H2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hpl-1 | |||||||
| Sequence_name | K08H2.6 | ||||||||
| Molecular_name | K08H2.6 | ||||||||
| K08H2.6.1 | |||||||||
| CE06164 | |||||||||
| Other_name | CELE_K08H2.6 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | hpl-1 | ||||||||
| DB_info | Database | AceView | gene | XN865 | |||||
| WormQTL | gene | WBGene00001995 | |||||||
| WormFlux | gene | WBGene00001995 | |||||||
| NDB | locus_tag | CELE_K08H2.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001995|UniProtKB=G5EET5 | |||||||
| family | PTHR22812 | ||||||||
| NCBI | gene | 181450 | |||||||
| RefSeq | protein | NM_077798.5 | |||||||
| SwissProt | UniProtAcc | G5EET5 | |||||||
| TREEFAM | TREEFAM_ID | TF350503 | |||||||
| UniProt_GCRP | UniProtAcc | G5EET5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hpl | ||||||||
| Allele (36) | |||||||||
| Strain | WBStrain00027446 | ||||||||
| WBStrain00027455 | |||||||||
| WBStrain00027510 | |||||||||
| WBStrain00029772 | |||||||||
| WBStrain00030671 | |||||||||
| WBStrain00031793 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00000414 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00007615 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020463 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | hpl-1 encodes one of two C. elegans heterochromatin protein 1 (HP1) homologs; loss of hpl-1 activity alone results in no obvious defects, but animals doubly mutant for hpl-1 and hpl-2 have defects in larval, somatic gonad and germline development; in addition, hpl-1 functions redundantly with hpl-2 and lin-13 in vulval development; rescuing HPL-1::GFP fusion proteins are expressed in nuclei throughout the life cycle, beginning at approximately the 50-cell stage of embryogenesis and continuing through larval and adult stages; expression is observed in most, but not all, cells and is particularly strong in head and tail hypodermal and neuronal nuclei; in nuclei, HPL-1::GFP is seen in foci that do not significantly overlap with those of HPL-2. | Paper_evidence | WBPaper00005176 | |||||
| WBPaper00028349 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 May 2007 00:00:00 | ||||||||
| Automated_description | Enables enzyme binding activity and methylated histone binding activity. Involved in several processes, including developmental process involved in reproduction; negative regulation of vulval development; and positive regulation of growth rate. Located in nucleus. Part of heterochromatin. Expressed in several structures, including neurons. Human ortholog(s) of this gene implicated in lung adenocarcinoma and prostate cancer. Is an ortholog of human CBX3 (chromobox 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1555) | ||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1551,HGNC:1553,HGNC:1555) | ||||||
| Molecular_info | Corresponding_CDS | K08H2.6 | |||||||
| Corresponding_transcript | K08H2.6.1 | ||||||||
| Associated_feature | WBsf648654 | ||||||||
| WBsf648655 | |||||||||
| WBsf1007574 | |||||||||
| WBsf1007575 | |||||||||
| WBsf236550 | |||||||||
| WBsf236551 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr1856 | ||||||||
| Expr3966 | |||||||||
| Expr3967 | |||||||||
| Expr1026379 | |||||||||
| Expr1031160 | |||||||||
| Expr1154060 | |||||||||
| Expr2012553 | |||||||||
| Expr2030790 | |||||||||
| Drives_construct | WBCnstr00009603 | ||||||||
| WBCnstr00010489 | |||||||||
| WBCnstr00011788 | |||||||||
| WBCnstr00011789 | |||||||||
| WBCnstr00036532 | |||||||||
| Construct_product | WBCnstr00009603 | ||||||||
| WBCnstr00010489 | |||||||||
| WBCnstr00011788 | |||||||||
| WBCnstr00011789 | |||||||||
| WBCnstr00036532 | |||||||||
| Regulate_expr_cluster | WBPaper00041609:hpl-1_hpl-2_downregulated | ||||||||
| WBPaper00041609:hpl-1_hpl-2_upregulated | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (103) | |||||||||
| Interaction (80) | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | X | Position | 10.5225 | Error | 0.096838 | |||
| Positive | Positive_clone | K08H2 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4933 | |||||||
| 5082 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (31) | |||||||||
| Remark | Sequence connection from [Couteau F, Muller F, Palladino F], 02/06/13 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
