WormBase Tree Display for Gene: WBGene00002031
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WBGene00002031 | SMap | S_parent | Sequence | Y34B4A | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | hst | |||||
Allele (56) | ||||||
Strain | WBStrain00029287 | |||||
WBStrain00029319 | ||||||
WBStrain00029330 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (11) | ||||||
Ortholog (46) | ||||||
Structured_description | Concise_description | hst-6 encodes the C. elegans ortholog of the heparan sulfate modifying enzyme heparan 6O-sulfotransferase; by homology, HST-6 is predicted to function in heparan sulfate biosynthesis by catalyzing the chain-modifying sulfation of the C6 hydroxyl group of the glucosamine subunits; during development, hst-6 activity is required for normal body size and nervous system development; an hst-6::gfp transcriptional reporter fusion is expressed beginning at early embryonic stages and continuing through adulthood; expression in embryos is nearly ubiquitous with later expression primarily restricted to neuronal tissues. | Paper_evidence | WBPaper00006471 | ||
WBPaper00029002 | ||||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 26 Oct 2007 00:00:00 | |||||
Automated_description | Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and regulation of growth. Predicted to be located in membrane. Expressed in AIBL; AIBR; RIML; RIMR; and neurons. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Is an ortholog of human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model | DOID:0111843 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19133) | |
DOID:0090075 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5201) | |||
Molecular_info | Corresponding_CDS | Y34B4A.3 | ||||
Corresponding_CDS_history | Y34B4A.3:wp86 | |||||
Corresponding_transcript | Y34B4A.3.1 | |||||
Other_sequence (28) | ||||||
Associated_feature | WBsf648093 | |||||
WBsf662771 | ||||||
WBsf1005223 | ||||||
WBsf235701 | ||||||
Experimental_info | RNAi_result | WBRNAi00020191 | Inferred_automatically | RNAi_primary | ||
WBRNAi00055817 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr2901 | |||||
Expr12886 | ||||||
Expr1014721 | ||||||
Expr1031186 | ||||||
Expr1159347 | ||||||
Expr2012637 | ||||||
Expr2030873 | ||||||
Drives_construct | WBCnstr00011014 | |||||
WBCnstr00016152 | ||||||
WBCnstr00036509 | ||||||
Construct_product | WBCnstr00005444 | |||||
WBCnstr00005695 | ||||||
WBCnstr00005696 | ||||||
WBCnstr00005697 | ||||||
WBCnstr00005699 | ||||||
WBCnstr00005700 | ||||||
WBCnstr00005701 | ||||||
WBCnstr00005702 | ||||||
WBCnstr00005703 | ||||||
WBCnstr00036509 | ||||||
Microarray_results (17) | ||||||
Expression_cluster (104) | ||||||
Interaction (12) | ||||||
Anatomy_function | WBbtf0285 | |||||
Map_info (4) | ||||||
Reference (29) | ||||||
Remark | Sequence connection from [Turnbull J, Kinnunen T]. krb 13/11/01 | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |