WormBase Tree Display for Gene: WBGene00002048
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WBGene00002048 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | B0244 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ida | ||||||
Allele (167) | |||||||
Strain | WBStrain00003830 | ||||||
WBStrain00003831 | |||||||
WBStrain00003832 | |||||||
WBStrain00035598 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (39) | |||||||
Paralog (64) | |||||||
Structured_description | Concise_description | ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles. | Paper_evidence | WBPaper00004433 | |||
WBPaper00004518 | |||||||
WBPaper00019367 | |||||||
WBPaper00019564 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Involved in positive regulation of anterior/posterior axon guidance; positive regulation of neurotransmitter secretion; and ventral cord development. Located in dense core granule and synapse. Expressed in several structures, including buccal cavity; neurons; preanal ganglion; somatic nervous system; and uv1. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Is an ortholog of human PTPRN2 (protein tyrosine phosphatase receptor type N2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00046108 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 28 Feb 2017 00:00:00 | ||||||
DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00046108 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 04 Feb 2015 00:00:00 | ||||||
Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9676,HGNC:9677) | |||
DOID:11716 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9677) | ||||
Models_disease_in_annotation | WBDOannot00000345 | ||||||
WBDOannot00000388 | |||||||
Molecular_info | Corresponding_CDS | B0244.2 | |||||
Corresponding_CDS_history | B0244.2:wp86 | ||||||
B0244.2b:wp18 | |||||||
Corresponding_transcript | B0244.2.1 | ||||||
Other_sequence (97) | |||||||
Associated_feature (18) | |||||||
Experimental_info | RNAi_result | WBRNAi00000950 | Inferred_automatically | RNAi_primary | |||
WBRNAi00038791 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038790 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00028026 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009628 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005822 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009627 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (14) | |||||||
Drives_construct (12) | |||||||
Construct_product | WBCnstr00000646 | ||||||
WBCnstr00005801 | |||||||
WBCnstr00006969 | |||||||
WBCnstr00008654 | |||||||
WBCnstr00018579 | |||||||
WBCnstr00036495 | |||||||
Antibody | WBAntibody00000901 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (299) | |||||||
Interaction (63) | |||||||
Map_info | Map | III | Position | -1.44641 | Error | 6.5e-05 | |
Positive | Positive_clone | B0244 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4431 | |||||
Pseudo_map_position | |||||||
Reference (32) | |||||||
Remark | Sequence connection from [Zahn TA, Macmorris MA] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |