WormBase Tree Display for Gene: WBGene00002074
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| WBGene00002074 | SMap | S_parent | Sequence | F32E10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ima-3 | |||||||
| Sequence_name | F32E10.4 | ||||||||
| Molecular_name | F32E10.4 | ||||||||
| F32E10.4.1 | |||||||||
| CE20745 | |||||||||
| Other_name | CELE_F32E10.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | ima-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ima | ||||||||
| Allele (36) | |||||||||
| Strain | WBStrain00002925 | ||||||||
| WBStrain00035796 | |||||||||
| Component_of_genotype | WBGenotype00000103 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (52) | |||||||||
| Paralog | WBGene00002072 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00002073 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009956 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ima-3 encodes one of three C. elegans importin alpha nuclear transport factors and the importin alpha that is most similar to the alpha3-subtype; ima-3 activity is required throughout development: during oogenesis, ima-3 is essential for progression past pachytene of meiotic prophase I and for proper organization of the nuclear pore complex (NPC) as well as association of P granules with the NPC; ima-3 is also required for normal embryonic, larval, and germline development; in vitro, IMA-3 can interact with human importin beta1, suggesting that it functions in a complex with C. elegans importin betas in vivo; IMA-3 is expressed in males and hermaphrodites, in both the germline and in somatic tissue; in the germline, IMA-3 is seen in the common cytoplasm of the rachis and in association with the nuclear envelope of germline nuclei and the residual body of developing spermatids. | Paper_evidence | WBPaper00004711 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Oct 2006 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor binding activity; nuclear import signal receptor activity; and nuclear localization sequence binding activity. Involved in several processes, including NLS-bearing protein import into nucleus; cellular component organization; and nematode larval development. Located in cytoplasm and nuclear envelope. Part of nuclear pore. Expressed in germ line; gonad; hypodermis; muscle cell; and neurons. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Is an ortholog of human KPNA3 (karyopherin subunit alpha 3) and KPNA4 (karyopherin subunit alpha 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6396) | ||||
| Modifies_disease | DOID:332 | ||||||||
| DOID:9255 | |||||||||
| Modifies_disease_in_annotation | WBDOannot00001147 | ||||||||
| WBDOannot00001148 | |||||||||
| Molecular_info | Corresponding_CDS | F32E10.4 | |||||||
| Corresponding_transcript | F32E10.4.1 | ||||||||
| Other_sequence (86) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern | Chronogram771 | ||||||||
| Expr1342 | |||||||||
| Expr1343 | |||||||||
| Expr14698 | |||||||||
| Expr1025205 | |||||||||
| Expr1031227 | |||||||||
| Expr1150033 | |||||||||
| Expr2012727 | |||||||||
| Expr2030964 | |||||||||
| Drives_construct | WBCnstr00003437 | ||||||||
| WBCnstr00036473 | |||||||||
| WBCnstr00041294 | |||||||||
| Construct_product | WBCnstr00036473 | ||||||||
| Antibody | WBAntibody00000369 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (482) | |||||||||
| Map_info | Map | IV | Position | 3.35651 | Error | 0.000664 | |||
| Positive | Positive_clone | F32E10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4439 | |||||||
| Pseudo_map_position | |||||||||
| Reference (24) | |||||||||
| Remark | Sequence connection from [Geles KG, Adam SA]. krb 13/11/01 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
