WormBase Tree Display for Gene: WBGene00002179
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| WBGene00002179 | Evidence | Paper_evidence | WBPaper00005001 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T22C1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | jph-1 | Person_evidence | WBPerson459 | |||||
| Sequence_name | T22C1.7 | ||||||||
| Molecular_name | T22C1.7 | ||||||||
| T22C1.7.1 | |||||||||
| CE30566 | |||||||||
| Other_name | JP | ||||||||
| CELE_T22C1.7 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | jph-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | jph | ||||||||
| Allele (72) | |||||||||
| Strain | WBStrain00037229 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (51) | |||||||||
| Structured_description | Concise_description | jph-1 encodes a junctophilin, a protein that belongs to a transmembrane family of proteins implicated in the formation of the junctional membrane complex that forms between the plasma membrane and the endoplasmic reticulum in excitable cells; this complex facilitates cross-talk between the cell surface and intracellular ionic channels; RNA interference of jph-1 results in a locomotion defect suggesting impaired body-wall muscle function; a jph-1 promoter-gfp fusion reporter is expressed in all muscle cells and certain neurons of the nerve ring. | Paper_evidence | WBPaper00005001 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable structural molecule activity. Involved in locomotion and positive regulation of engulfment of apoptotic cell. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be part of junctional membrane complex. Expressed in body wall musculature; muscle cell; and nerve ring. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2K; Huntington's disease-like 2; and intrinsic cardiomyopathy (multiple). Is an ortholog of human JPH3 (junctophilin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110323 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14202) | ||||
| DOID:0090104 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14203) | ||||||
| DOID:0081161 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14202) | ||||||
| DOID:0110167 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14201) | ||||||
| Molecular_info | Corresponding_CDS | T22C1.7 | |||||||
| Corresponding_CDS_history | T22C1.7:wp77 | ||||||||
| Corresponding_transcript | T22C1.7.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00053811 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00116592 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097815 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026354 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065168 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026355 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004263 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1724 | ||||||||
| Expr1935 | |||||||||
| Expr3200 | |||||||||
| Expr15971 | |||||||||
| Expr15972 | |||||||||
| Expr1019027 | |||||||||
| Expr1031274 | |||||||||
| Expr1157358 | |||||||||
| Expr2012895 | |||||||||
| Expr2031129 | |||||||||
| Drives_construct | WBCnstr00010417 | ||||||||
| WBCnstr00010527 | |||||||||
| WBCnstr00011213 | |||||||||
| WBCnstr00036406 | |||||||||
| WBCnstr00042623 | |||||||||
| Construct_product | WBCnstr00036406 | ||||||||
| WBCnstr00042623 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (161) | |||||||||
| Interaction (51) | |||||||||
| Map_info | Map | I | Position | 2.41451 | Error | 0.001218 | |||
| Positive | Positive_clone | T22C1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
