WormBase Tree Display for Gene: WBGene00003056
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WBGene00003056 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lon | ||||||
Reference_allele | WBVar00143398 | ||||||
Allele (213) | |||||||
Legacy_information | e678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678). | ||||||
[C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974] | |||||||
Strain (224) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (19) | |||||||
Ortholog (25) | |||||||
Structured_description | Concise_description | lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. | Paper_evidence | WBPaper00029002 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 24 Jan 2007 00:00:00 | ||||||
Automated_description | Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C39E6.1 | |||||
Corresponding_CDS_history | C39E6.1:wp107 | ||||||
Corresponding_transcript | C39E6.1.1 | ||||||
Other_sequence (6) | |||||||
Associated_feature (15) | |||||||
Experimental_info (7) | |||||||
Map_info | Map | X | Position | -6.74013 | Error | 0.007834 | |
Well_ordered | |||||||
Positive | Inside_rearr | mnDp30 | |||||
yDp4 | |||||||
Positive_clone | C39E6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
F43C9 | |||||||
Negative | Outside_rearr | mcDf2 | |||||
Mapping_data | 2_point (57) | ||||||
Multi_point (150) | |||||||
Pos_neg_data (31) | |||||||
Landmark_gene | |||||||
Reference (155) | |||||||
Remark | sequence wsa incorrectly given as F43C9.3 | ||||||
Method | Gene |