[Golden A] Mutation is defective in metaphase to anaphase transition.
[Sundaram M] ku233 homozygotes exhibit abnormal vulval development, beginning with abnormal appearance of the Pn.pxx nuclei from both primary and secondary lineages.
mat-3 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of CDC23/APC8, a conserved regulatory subunit of the anaphase-promoting complex; mat-3 activity is required for progression through metaphase of oocyte meiosis I, germline proliferation, and vulval development.
Predicted to enable molecular adaptor activity. Involved in asymmetric cell division; polarity specification of anterior/posterior axis; and positive regulation of metaphase/anaphase transition of meiosis I. Predicted to be part of anaphase-promoting complex. Is an ortholog of human CDC23 (cell division cycle 23).