WormBase Tree Display for Gene: WBGene00003143
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| WBGene00003143 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | max-1 | Person_evidence | WBPerson105 | |||||
| WBPerson293 | |||||||||
| Sequence_name | C34B4.1 | ||||||||
| Molecular_name | C34B4.1a | ||||||||
| C34B4.1a.1 | |||||||||
| CE40604 | |||||||||
| C34B4.1b | |||||||||
| CE40605 | |||||||||
| C34B4.1a.2 | |||||||||
| C34B4.1a.3 | |||||||||
| C34B4.1b.1 | |||||||||
| Other_name | frm-6 | ||||||||
| CELE_C34B4.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | max-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00003143 | |||||
| WormFlux | gene | WBGene00003143 | |||||||
| NDB | locus_tag | CELE_C34B4.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003143|UniProtKB=G5ED24 | |||||||
| family | PTHR22903 | ||||||||
| NCBI | gene | 179794 | |||||||
| RefSeq | protein | NM_001392634.1 | |||||||
| NM_001380794.1 | |||||||||
| TREEFAM | TREEFAM_ID | TF312866 | |||||||
| TrEMBL | UniProtAcc | Q18420 | |||||||
| G5ED24 | |||||||||
| UniProt_GCRP | UniProtAcc | G5ED24 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | max | ||||||||
| Allele (306) | |||||||||
| Strain | WBStrain00003026 | ||||||||
| WBStrain00037665 | |||||||||
| WBStrain00005366 | |||||||||
| WBStrain00005367 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00012992 | ||||||||
| 00110610 | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | max-1 encodes a novel, conserved PH/MyTH4/FERM domain-containing protein; max-1 activityis required cell-autonomously in motor neurons for UNC-6-mediated, dorsally directed axon guidance, proper axon extension and axon fasciculation in the nerve cords, and fully normal backward locomotion; genetic analyses indicate that max-1 likely acts downstream of unc-6 and unc-5, and in parallel to unc-40 and unc-129, to regulate axon guidance; max-1 expression begins during later stages of embryogenesis and continues through adulthood; expression is seen in motor neurons that extend circumferential processes, other neurons and, for the short form of MAX-1, body wall muscles; in neurons, MAX-1 localizes to processes but is excluded from cell bodies in a manner dependent upon the FERM domain, which appears critical for MAX-1 function. | Paper_evidence | WBPaper00005251 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Oct 2006 00:00:00 | ||||||||
| Automated_description | Involved in motor neuron axon guidance. Predicted to be located in cytoskeleton. Expressed in neurons. Is an ortholog of human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1) and PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C34B4.1a | |||||||
| C34B4.1b | |||||||||
| Corresponding_CDS_history | C34B4.1:wp87 | ||||||||
| Corresponding_transcript | C34B4.1a.1 | ||||||||
| C34B4.1a.2 | |||||||||
| C34B4.1a.3 | |||||||||
| C34B4.1b.1 | |||||||||
| Other_sequence (34) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00000633 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00108518 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009730 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041833 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114831 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065305 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067496 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011572 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1288 | ||||||||
| Expr1897 | |||||||||
| Expr1021140 | |||||||||
| Expr1031482 | |||||||||
| Expr1145847 | |||||||||
| Expr2013427 | |||||||||
| Expr2031661 | |||||||||
| Drives_construct | WBCnstr00003526 | ||||||||
| WBCnstr00009537 | |||||||||
| WBCnstr00010508 | |||||||||
| WBCnstr00036218 | |||||||||
| Construct_product | WBCnstr00010508 | ||||||||
| WBCnstr00036218 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (214) | |||||||||
| Interaction (30) | |||||||||
| Anatomy_function | WBbtf0090 | ||||||||
| Map_info | Map | V | Position | 4.87806 | Error | 0.017534 | |||
| Positive | Positive_clone | C34B4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4482 | |||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | This gene was previously described (incorrectly) as being another name for mxl-1. [krb 020614] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
