WormBase Tree Display for Gene: WBGene00003163
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| WBGene00003163 | SMap | S_parent | Sequence | R03E9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mdl-1 | |||||||
| Sequence_name | R03E9.1 | ||||||||
| Molecular_name | R03E9.1 | ||||||||
| R03E9.1.1 | |||||||||
| CE04784 | |||||||||
| Other_name | CELE_R03E9.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mdl-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mdl | ||||||||
| Allele (35) | |||||||||
| Legacy_information | [Yuan J, Cole MD] No mutations known. Related to vertebrate MAD transcription factor, MDL-1 can form DNA-binding heterodimer with MXL-1 in vitro. mdl-1::GFP expression strongest in intestinal cells. Predicted gene R03E9.1. | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (41) | |||||||||
| Structured_description (2) | |||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035654 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Potential_model | DOID:3512 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7534) | |||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7534) | ||||||
| Disease_relevance | mdl-1 encodes a bHLH (basic-helix-loop-helix) protein similar to the vertebrate MAD transcriptional regulators; mdl-1 is a candidate target gene for the small non-coding RNAs mir-64 and mir-65, and is found to be over-expressed in an transgenic elegans model for Parkinson''s disease, expressing human A53T alpha-synuclein, as well as in mir-64/mir-65 knock-out animals; mir-64 and mir-65 are co-underexpressed in the same model, suggesting a role for all of these genes in disease pathogenesis. | Homo sapiens | Paper_evidence | WBPaper00035654 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000270 | ||||||||
| Molecular_info | Corresponding_CDS | R03E9.1 | |||||||
| Corresponding_transcript | R03E9.1.1 | ||||||||
| Other_sequence (53) | |||||||||
| Associated_feature (18) | |||||||||
| Gene_product_binds (5628) | |||||||||
| Transcription_factor | WBTranscriptionFactor000088 | ||||||||
| WBTranscriptionFactor000010 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00004922 | ||||||||
| WBCnstr00007729 | |||||||||
| WBCnstr00012495 | |||||||||
| WBCnstr00012773 | |||||||||
| WBCnstr00012774 | |||||||||
| WBCnstr00036207 | |||||||||
| WBCnstr00041557 | |||||||||
| Construct_product | WBCnstr00007729 | ||||||||
| WBCnstr00016903 | |||||||||
| WBCnstr00036207 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (230) | |||||||||
| Interaction (38) | |||||||||
| Product_binds_matrix | WBPmat00005548 | ||||||||
| WBPmat00005576 | |||||||||
| Map_info | Map | X | Position | -2.50858 | Error | 0.015767 | |||
| Positive | Positive_clone | R03E9 | Author_evidence | Yuan JY | |||||
| Cole MD | |||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4665 | |||||||
| 5031 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Data extracted from Yuan et al. (1998) | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
