WormBase Tree Display for Gene: WBGene00003232
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| WBGene00003232 | SMap | S_parent | Sequence | ZC506 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mgl-1 | Person_evidence | WBPerson309 | |||||
| Sequence_name | ZC506.4 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_ZC506.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mgl-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00003232 | |||||
| WormFlux | gene | WBGene00003232 | |||||||
| NDB | locus_tag | CELE_ZC506.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003232|UniProtKB=Q09630 | |||||||
| family | PTHR24060 | ||||||||
| NCBI | gene | 191707 | |||||||
| RefSeq | protein | NM_001313458.3 | |||||||
| NM_001129721.4 | |||||||||
| NM_001313459.3 | |||||||||
| NM_077273.4 | |||||||||
| SwissProt | UniProtAcc | Q09630 | |||||||
| TrEMBL | UniProtAcc | A0A0K3AWH7 | |||||||
| A3FPK2 | |||||||||
| A0A0K3ASV1 | |||||||||
| UniProt_GCRP | UniProtAcc | Q09630 | |||||||
| OMIM | gene | 604096 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mgl | ||||||||
| Allele (129) | |||||||||
| Strain | WBStrain00005599 | ||||||||
| WBStrain00055288 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00003233 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00021152 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00018073 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016242 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mgl-1 encodes a Group II metabotropic glutamate receptor (OMIM:604099, loss-of-function mutations in mice are associated with defects in long-term depression); by homology, MGL-1 is predicted to function as a pre-synaptic G protein-coupled receptor that, in response to glutamate binding, inhibits adenylyl cyclase activity; loss of mgl-1 activity reduces the excess fat of daf-7 mutants, indicating that mgl-1 plays a role in regulation of fat accumulation; in addition, loss of mgl-1 activity via large-scale RNAi screens indicates that, in C. elegans, MGL-1 is required for normal post-embryonic growth rates; an mgl-1::GFP reporter is expressed in interneurons, motor neurons, and pharyngeal neurons. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00022392 | |||||||||
| WBPaper00028607 | |||||||||
| WBPaper00032082 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Jun 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable group II metabotropic glutamate receptor activity. Involved in positive regulation of lipid storage. Predicted to be located in plasma membrane. Expressed in nerve ring; neurons; and pharyngeal nervous system. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autistic disorder; and congenital stationary night blindness 1B. Is an ortholog of human GRM3 (glutamate metabotropic receptor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1094 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4600) | ||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4600) | ||||||
| DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4600) | ||||||
| DOID:0110865 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4598) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4600) | ||||||
| Molecular_info | Corresponding_CDS | ZC506.4a | |||||||
| ZC506.4b | |||||||||
| ZC506.4c | |||||||||
| ZC506.4d | |||||||||
| Corresponding_CDS_history | ZC506.4a:wp246 | ||||||||
| ZC506.4b:wp246 | |||||||||
| Corresponding_transcript | ZC506.4a.1 | ||||||||
| ZC506.4b.1 | |||||||||
| ZC506.4c.1 | |||||||||
| ZC506.4d.1 | |||||||||
| Other_sequence | JI220720.1 | ||||||||
| JI179605.1 | |||||||||
| JI180213.1 | |||||||||
| JI179185.1 | |||||||||
| CJC03032_1 | |||||||||
| JI217902.1 | |||||||||
| Associated_feature | WBsf654293 | ||||||||
| WBsf670912 | |||||||||
| WBsf945408 | Paper_evidence | WBPaper00044605 | |||||||
| WBsf1006581 | |||||||||
| WBsf1006582 | |||||||||
| WBsf1006583 | |||||||||
| WBsf1006584 | |||||||||
| WBsf1023646 | |||||||||
| WBsf1023647 | |||||||||
| WBsf1023648 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00009442 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00058985 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00013207 | ||||||||
| WBCnstr00015040 | |||||||||
| WBCnstr00015434 | |||||||||
| WBCnstr00018705 | |||||||||
| WBCnstr00020467 | |||||||||
| WBCnstr00036172 | |||||||||
| WBCnstr00039530 | |||||||||
| Construct_product | WBCnstr00020467 | ||||||||
| WBCnstr00036172 | |||||||||
| WBCnstr00040528 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction (17) | |||||||||
| Map_info | Map | X | Position | 1.73178 | Error | 0.000248 | |||
| Positive | Positive_clone | ZC506 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5083 | |||||||
| 4879 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (35) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
