WormBase Tree Display for Gene: WBGene00003243
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WBGene00003243 | SMap | S_parent | Sequence | F10E9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | mig | ||||||
Allele (291) | |||||||
Possibly_affected_by | WBVar02157219 | ||||||
Legacy_information | [C.elegansII] ct41 : incomplete CAN, HSN, ALM migrations; shortened excretory canals; additional defects. Mosaic analysis indicates non-autonomy, possible hypodermal focus. OA1: e2527. Cloned: encodes predicted 650 aa protein with similarity to human Grb7, Grb10, including pleckstrin homology domain. [Desai et al. 1988; LK] | ||||||
Strain | WBStrain00001485 | ||||||
WBStrain00002915 | |||||||
WBStrain00003479 | |||||||
WBStrain00033874 | |||||||
WBStrain00032605 | |||||||
WBStrain00003959 | |||||||
WBStrain00051958 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (27) | |||||||
Ortholog (38) | |||||||
Structured_description | Concise_description | mig-10 encodes proteins that contain, from N- to C-terminus, an RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and a proline-rich motif, and that are homologous to the vertebrate RIAM, lamellopodin, and Grb7, Grb10, and Grb14 cytoplasmic adaptor proteins; during development, mig-10 activity is required for cell migration and for outgrowth of axons and excretory cell canals; in regulating axon outgrowth, MIG-10 likely functions downstream of UNC-6/Netrin and SLT-1/Slit and in concert with UNC-34, with which it interacts in vitro; MIG-10 also physically interacts with ABI-1 (Abelson interactor-1); mig-10::gfp reporter fusions are expressed in neurons as well as in pharyngeal and intestinal tissue; when expressed in tissue culture cells, a MIG-10::GFP fusion protein colocalizes with F-actin and promotes lamellipodia formation. | Paper_evidence | WBPaper00001304 | |||
WBPaper00002766 | |||||||
WBPaper00027185 | |||||||
WBPaper00027328 | |||||||
WBPaper00041596 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 13 Nov 2012 00:00:00 | ||||||
Automated_description | Enables SH3 domain binding activity. Involved in several processes, including cell migration; cell projection organization; and egg-laying behavior. Located in neuronal cell body membrane; plasma membrane bounded cell projection; and presynaptic cytosol. Part of filamentous actin. Expressed in hermaphrodite gonad; neurons; and tail. Is an ortholog of human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F10E9.6a | |||||
F10E9.6b | |||||||
F10E9.6c | |||||||
Corresponding_CDS_history | F10E9.6a:wp113 | ||||||
F10E9.6b:wp113 | |||||||
Corresponding_transcript | F10E9.6a.1 | ||||||
F10E9.6a.2 | |||||||
F10E9.6a.3 | |||||||
F10E9.6b.1 | |||||||
F10E9.6c.1 | |||||||
Other_sequence (28) | |||||||
Associated_feature (66) | |||||||
Experimental_info | RNAi_result (22) | ||||||
Expr_pattern (27) | |||||||
Drives_construct | WBCnstr00001004 | ||||||
WBCnstr00003428 | |||||||
WBCnstr00004230 | |||||||
WBCnstr00011701 | |||||||
WBCnstr00013113 | |||||||
WBCnstr00016488 | |||||||
WBCnstr00017477 | |||||||
WBCnstr00017478 | |||||||
WBCnstr00017479 | |||||||
Construct_product (12) | |||||||
Microarray_results (45) | |||||||
Expression_cluster (181) | |||||||
Interaction (65) | |||||||
Anatomy_function | WBbtf0493 | ||||||
WBbtf0494 | |||||||
WBbtf0815 | |||||||
Map_info | Map | III | Position | -0.346394 | Error | 0.001792 | |
Well_ordered | |||||||
Positive | Positive_clone | F10E9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point (11) | ||||||
Pos_neg_data | 4231 | ||||||
4232 | |||||||
4975 | |||||||
Reference (58) | |||||||
Method | Gene |