WormBase Tree Display for Gene: WBGene00003396
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| WBGene00003396 | SMap | S_parent | Sequence | F52F12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mom-4 | Person_evidence | WBPerson498 | |||||
| Sequence_name | F52F12.3 | ||||||||
| Molecular_name | F52F12.3 | ||||||||
| F52F12.3.1 | |||||||||
| CE24994 | |||||||||
| Other_name | CELE_F52F12.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mom-4 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mom | ||||||||
| Allele (94) | |||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Contained_in_operon | CEOP1921 | ||||||||
| Ortholog (33) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | mom-4 encodes a MAP kinase kinase kinase-related protein orthologous to Drosophila Tak1 and the vertebrate MAPKKK7 proteins; during embryonic development, mom-4 activity is required for positive regulation of the Wnt pathway signaling that governs anterior/posterior (A/P) polarity: MOM-4 stimulates the WRM-1/LIT-1-dependent phosphorylation of POP-1, a TCF/LEF-related transcription factor, leading to its downregulation in posterior daughters of A/P cell divisions. | Paper_evidence | WBPaper00003574 | |||||
| WBPaper00003656 | |||||||||
| WBPaper00006492 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 06 Dec 2006 00:00:00 | ||||||||
| Automated_description | Enables MAP kinase kinase kinase activity. Involved in several processes, including cell fate commitment; embryonic digestive tract morphogenesis; and signal transduction. Located in striated muscle dense body. Expressed in BAGL and BAGR. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); frontometaphyseal dysplasia 2; and intrinsic cardiomyopathy (multiple). Is an ortholog of human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111785 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6859) | ||||
| DOID:11520 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6859) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6859) | ||||||
| DOID:11984 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6859) | ||||||
| DOID:0111787 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6859) | ||||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6859) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6859) | ||||||
| Molecular_info | Corresponding_CDS | F52F12.3 | |||||||
| Corresponding_transcript | F52F12.3.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf649528 | ||||||||
| WBsf664799 | |||||||||
| WBsf664800 | |||||||||
| WBsf220159 | |||||||||
| WBsf220160 | |||||||||
| Experimental_info | RNAi_result (34) | ||||||||
| Expr_pattern | Expr9388 | ||||||||
| Expr12436 | |||||||||
| Expr1024331 | |||||||||
| Expr1031568 | |||||||||
| Expr1151824 | |||||||||
| Expr2013657 | |||||||||
| Expr2031891 | |||||||||
| Drives_construct | WBCnstr00021073 | ||||||||
| WBCnstr00036140 | |||||||||
| Construct_product | WBCnstr00009518 | ||||||||
| WBCnstr00013953 | |||||||||
| WBCnstr00016238 | |||||||||
| WBCnstr00021073 | |||||||||
| WBCnstr00036140 | |||||||||
| WBCnstr00042642 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (82) | |||||||||
| Map_info | Map | I | Position | 3.98835 | Error | 0.006562 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | qDf9 | |||||||
| Positive_clone | F52F12 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | nDf29 | |||||||
| qDf10 | |||||||||
| Mapping_data | Multi_point | 5060 | |||||||
| Pos_neg_data | 10551 | ||||||||
| 10552 | |||||||||
| 10553 | |||||||||
| Reference (69) | |||||||||
| Picture | WBPicture0000013084 | ||||||||
| Method | Gene |
