WormBase Tree Display for Gene: WBGene00003404
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| WBGene00003404 | Evidence | Person_evidence | WBPerson1870 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPerson3043 | |||||||||
| Author_evidence | |||||||||
| SMap | S_parent | Sequence | CHROMOSOME_II | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mpz-1 | |||||||
| Sequence_name | C52A11.4 | ||||||||
| Molecular_name (30) | |||||||||
| Other_name | CELE_C52A11.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | mpz-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mpz | ||||||||
| Allele (565) | |||||||||
| Strain | WBStrain00035872 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00012873 | ||||||||
| 00012874 | |||||||||
| 00012875 | |||||||||
| 00012876 | |||||||||
| 00012877 | |||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00001492 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00021406 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mpz-1 encodes a multi-PDZ domain scaffold protein; mpz-1(RNAi) animals have reduced serotonin (5-HT)-stimulated egg laying unless truncated SER-1 is transgenically expressed in vulval muscle; overexpressed MPZ-1 PDZ domain 10 also reduces SER-1-mediated egg laying; the PDZ domain 10 of MPZ-1 binds the C-terminal PDZ-binding motif (ETFL) of the 5-HT receptor SER-1; MPZ-1 also physically interacts with the RHGF-2 RhoGEF, and may also bind NPR-1 and ZC84.4; MPZ-1 binding enhances SER-1 activity; mpz-1 is expressed in the nerve ring, pharyngeal, body, and tail neurons, as well as body wall and vulval muscles; mpz-1 is coexpressed with ser-1 in three neuron types and vulval muscle; MPZ-1 co-localizes with SNB-1 in neuronal puncta and with RHGF-2 in nerve ring axons; mpz-1 may be translationally regulated by a small upstream open reading frame (uORF). | Paper_evidence | WBPaper00028370 | |||||
| WBPaper00040835 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Jun 2013 00:00:00 | ||||||||
| Automated_description | Enables GTPase activating protein binding activity. Located in axon. Expressed in body wall musculature; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human MPDZ (multiple PDZ domain crumbs cell polarity complex component) and PATJ (PATJ crumbs cell polarity complex component). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7208) | ||||
| Molecular_info | Corresponding_CDS | C52A11.4a | |||||||
| C52A11.4b | |||||||||
| C52A11.4c | |||||||||
| C52A11.4d | |||||||||
| C52A11.4e | |||||||||
| C52A11.4f | |||||||||
| C52A11.4g | |||||||||
| C52A11.4h | |||||||||
| C52A11.4i | |||||||||
| C52A11.4j | |||||||||
| Corresponding_CDS_history | C52A11.4:wp111 | ||||||||
| C52A11.4a:wp173 | |||||||||
| C52A11.4a:wp174 | |||||||||
| C52A11.4b:wp173 | |||||||||
| C52A11.4c:wp173 | |||||||||
| C52A11.4c:wp174 | |||||||||
| C52A11.4d:wp174 | |||||||||
| C52A11.4d:wp274 | |||||||||
| C52A11.4e:wp174 | |||||||||
| C52A11.4f:wp274 | |||||||||
| Corresponding_transcript | C52A11.4a.1 | ||||||||
| C52A11.4b.1 | |||||||||
| C52A11.4c.1 | |||||||||
| C52A11.4d.1 | |||||||||
| C52A11.4e.1 | |||||||||
| C52A11.4f.1 | |||||||||
| C52A11.4g.1 | |||||||||
| C52A11.4h.1 | |||||||||
| C52A11.4i.1 | |||||||||
| C52A11.4j.1 | |||||||||
| Other_sequence (69) | |||||||||
| Associated_feature (44) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00065442 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00012288 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077321 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043004 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065441 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00004933 | ||||||||
| WBCnstr00011781 | |||||||||
| WBCnstr00011782 | |||||||||
| WBCnstr00011783 | |||||||||
| WBCnstr00011784 | |||||||||
| WBCnstr00040676 | |||||||||
| Construct_product | WBCnstr00004933 | ||||||||
| WBCnstr00011784 | |||||||||
| WBCnstr00011785 | |||||||||
| Antibody | WBAntibody00001131 | ||||||||
| Microarray_results (50) | |||||||||
| Expression_cluster (212) | |||||||||
| Interaction (91) | |||||||||
| Map_info | Map | II | Position | 3.12519 | Error | 0.000174 | |||
| Positive | Positive_clone | C52A11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
