WormBase Tree Display for Gene: WBGene00003418
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| WBGene00003418 | SMap | S_parent | Sequence | H26D21 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | msh-2 | Person_evidence | WBPerson1547 | |||||
| Sequence_name | H26D21.2 | ||||||||
| Molecular_name | H26D21.2 | ||||||||
| H26D21.2.1 | |||||||||
| CE21000 | |||||||||
| Other_name | CELE_H26D21.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | msh-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | msh | ||||||||
| Allele (45) | |||||||||
| Strain | WBStrain00029136 | ||||||||
| WBStrain00032553 | |||||||||
| WBStrain00032598 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00001872 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003421 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003422 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436). | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00004424 | |||||||||
| WBPaper00005107 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable double-strand/single-strand DNA junction binding activity and mismatched DNA binding activity. Involved in DNA damage response; maintenance of DNA repeat elements; and reproduction. Predicted to be located in nucleus. Predicted to be part of MutSalpha complex. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); carcinoma (multiple); and cervix uteri carcinoma in situ. Is an ortholog of human MSH2 (mutS homolog 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (19) | ||||||||
| Molecular_info | Corresponding_CDS | H26D21.2 | |||||||
| Corresponding_transcript | H26D21.2.1 | ||||||||
| Other_sequence (31) | |||||||||
| Associated_feature | WBsf649040 | ||||||||
| WBsf983203 | |||||||||
| WBsf1009539 | |||||||||
| WBsf219168 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00116847 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003884 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112108 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064076 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022778 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049498 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112104 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033755 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1024403 | ||||||||
| Expr1031585 | |||||||||
| Expr1153220 | |||||||||
| Expr2013766 | |||||||||
| Expr2032001 | |||||||||
| Drives_construct | WBCnstr00036129 | ||||||||
| Construct_product | WBCnstr00036129 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (207) | |||||||||
| WBProcess | WBbiopr:00000058 | ||||||||
| WBbiopr:00000066 | |||||||||
| WBbiopr:00000091 | |||||||||
| Map_info | Positive | Positive_clone | H26D21 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Mapping_data | Multi_point | 4810 | |||||||
| Interpolated_map_position | I | -2.88532 | |||||||
| Reference (20) | |||||||||
| Remark | sequence connection from [Villeneuve AM] | ||||||||
| Method | Gene |
