WormBase Tree Display for Gene: WBGene00003422
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| WBGene00003422 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y47G6A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | msh-6 | Person_evidence | WBPerson1547 | |||||
| Sequence_name | Y47G6A.11 | ||||||||
| Molecular_name | Y47G6A.11 | ||||||||
| Y47G6A.11.1 | |||||||||
| CE28985 | |||||||||
| Other_name | Y47G6A_242.c | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y47G6A.11 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | msh-6 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | msh | ||||||||
| Allele (207) | |||||||||
| Strain | WBStrain00029001 | ||||||||
| WBStrain00033053 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Contained_in_operon | CEOP1096 | ||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00001872 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003418 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003421 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | msh-6 encodes a gene orthologous to human MSH6 (homolog of MutS), which is involved in post-replicative mismatch DNA repair (MMR); in elegans, msh-6 defective animals show an elevated level of spontaneous mutants in both the male and female germline; in elegans, similar to higher mammals, MMR surveillance is likely carried out by a MSH-2/MSH-6 heterodimer. | Paper_evidence | WBPaper00005340 | |||||
| WBPaper00024965 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Sep 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable four-way junction DNA binding activity and mismatched DNA binding activity. Involved in maintenance of DNA repeat elements and mismatch repair. Predicted to be located in nucleus. Predicted to be part of MutSalpha complex. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in several diseases, including colorectal carcinoma; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Is an ortholog of human MSH6 (mutS homolog 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:3883 | Homo sapiens | Paper_evidence | WBPaper00005340 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Jan 2019 00:00:00 | ||||||||
| Potential_model | DOID:3883 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7329) | |||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7329) | ||||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7329) | ||||||
| DOID:0080199 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7329) | ||||||
| DOID:3347 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7329) | ||||||
| DOID:0070272 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7329) | ||||||
| DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7329) | ||||||
| DOID:0112182 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7329) | ||||||
| Disease_relevance | In humans, the DNA mismatch repair complex consists of the MSH6 and MSH2 proteins, orthologous to the msh-6 and msh-2 genes in elegans; mutations in human MSH6 are associated with colorectal cancer, endometrial cancer, and Mismatch repair cancer syndrome. | Homo sapiens | Paper_evidence | WBPaper00024965 | |||||
| WBPaper00005340 | |||||||||
| Accession_evidence | OMIM | 614350 | |||||||
| 608089 | |||||||||
| 276300 | |||||||||
| 600678 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Sep 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000230 | ||||||||
| Molecular_info | Corresponding_CDS | Y47G6A.11 | |||||||
| Corresponding_transcript | Y47G6A.11.1 | ||||||||
| Other_sequence (67) | |||||||||
| Associated_feature | WBsf983147 | ||||||||
| WBsf1009506 | |||||||||
| WBsf217396 | |||||||||
| WBsf217397 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr1020857 | ||||||||
| Expr1031587 | |||||||||
| Expr1160255 | |||||||||
| Expr2013768 | |||||||||
| Expr2032003 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (161) | |||||||||
| Interaction (92) | |||||||||
| Map_info | Map | I | Position | -3.38426 | Error | 0.0772 | |||
| Positive | Positive_clone | Y47G6A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Sequence connection from [Boulton S, Vidal M] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
