WormBase Tree Display for Gene: WBGene00003567

WBGene00003567 SMap: S_parent: Sequence: C10G8
  Identity: Version: 1
    Name: CGC_name: ncx-2
      Sequence_name: C10G8.5
      Molecular_name (12)
      Other_name: CELE_C10G8.5 Accession_evidence: NDB BX284605
      Public_name: ncx-2
    DB_info: Database: AceView gene 5F787
        WormQTL gene WBGene00003567
        WormFlux gene WBGene00003567
        NDB locus_tag CELE_C10G8.5
        Panther gene CAEEL|WormBase=WBGene00003567|UniProtKB=H2KYP2
          family PTHR11878
        NCBI gene 178918
        RefSeq protein NM_001028473.5
            NM_072014.8
            NM_001028472.6
            NM_072013.8
        TREEFAM TREEFAM_ID TF314308
        TrEMBL UniProtAcc H2KYP2
            Q8I7I7
            H2KYP3
            H2KYP4
        UniProt_GCRP UniProtAcc H2KYP2
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ncx
    Allele (127)
    Legacy_information: [Kraev A] ncx for Na/Ca eXchanger. No mutants known. See ncx-1. Predicted gene C10G8.5 (except exon 1)
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (52)
    Paralog: WBGene00003566 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003568 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: ncx-2 encodes, by alternative splicing, three full-length isoforms of a putative 3Na[+]/1Ca[2+] exchanger, orthologous to human SLC8A1-3 and paralogous to NCX-1 and NCX-3; NCX-2 is predicted to export free cytoplasmic Ca[2+] with low affinity but high capacity, being complemented by low-capacity/high-affinity Ca[2+] ATPase pumps such as MCA-1/-3; NCX-3 has tandem Calx-alpha and Calx-beta domains predicted to carry out ion transport and regulation; NCX-1 is required for normally rapid growth in mass RNAi assays. Paper_evidence: WBPaper00006395
            WBPaper00012774
            WBPaper00028596
            WBPaper00031156
            WBPaper00031157
            WBPaper00031158
          Curator_confirmed: WBPerson567
          Date_last_updated: 07 Nov 2007 00:00:00
      Automated_description: Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to be located in axon; postsynapse; and sarcolemma. Expressed in non-striated muscle and pharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease and pulmonary hypertension. Is an ortholog of human SLC8A2 (solute carrier family 8 member A2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11068,HGNC:11069,HGNC:11070)
      DOID:6432 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11068)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11068)
  Molecular_info: Corresponding_CDS: C10G8.5a
      C10G8.5b
      C10G8.5c
      C10G8.5d
    Corresponding_transcript: C10G8.5a.1
      C10G8.5b.1
      C10G8.5c.1
      C10G8.5d.1
    Other_sequence (36)
    Associated_feature (21)
  Experimental_info: RNAi_result: WBRNAi00112437 Inferred_automatically: RNAi_primary
      WBRNAi00040324 Inferred_automatically: RNAi_primary
      WBRNAi00030216 Inferred_automatically: RNAi_primary
      WBRNAi00024526 Inferred_automatically: RNAi_primary
      WBRNAi00027169 Inferred_automatically: RNAi_primary
      WBRNAi00010610 Inferred_automatically: RNAi_primary
      WBRNAi00112436 Inferred_automatically: RNAi_primary
      WBRNAi00040325 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11156
      Expr1017552
      Expr1031625
      Expr1144396
      Expr2013919
      Expr2032159
    Drives_construct: WBCnstr00018016
      WBCnstr00036038
    Construct_product: WBCnstr00036038
    Microarray_results (42)
    Expression_cluster (209)
    Interaction (48)
  Map_info: Map: V Position: -2.31787 Error: 0.009836
    Positive: Positive_clone: C10G8 Author_evidence: Kraev A
          Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00011772
    WBPaper00038491
    WBPaper00046461
    WBPaper00052790
    WBPaper00055090
    WBPaper00062223
    WBPaper00064064
    WBPaper00065331
    WBPaper00066025
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene