WormBase Tree Display for Gene: WBGene00003592
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| WBGene00003592 | SMap | S_parent | Sequence | ZK1290 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nfi-1 | |||||||
| Sequence_name | ZK1290.4 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | gei-21 | ||||||||
| CELE_ZK1290.4 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | nfi-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nfi | ||||||||
| Allele (76) | |||||||||
| Legacy_information | [Gronostajski R] nfi for Nuclear Factor I. No mutants known. Predicted gene ZK1290.4 | ||||||||
| Strain | WBStrain00040597 | ||||||||
| WBStrain00051989 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (45) | |||||||||
| Structured_description | Concise_description | nfi-1 encodes the C. elegans ortholog of the Nuclear Factor I (NFI) family of transcription factors; in C. elegans, nfi-1 activity is required for locomotion, egg laying, pharyngeal pumping, and wild-type adult lifespan; in vitro, NFI-1 can bind conserved NFI-binding sites also recognized by vertebrate NFI proteins; in situ hybridization experiments indicate that nfi-1 is expressed maternally in the germline and the early embryo; mRNA expression is also seen in the adult intestine; an NFI-1::GFP fusion protein is expressed from late embryogenesis through adulthood where it is seen in muscles, particularly pharyngeal and head muscles, neurons, and the intestine; nfi-1 expression in pharyngeal muscle is sufficient to rescue pharyngeal pumping defects and lifespan abnormalities; expression of ttn-1, which encodes the C. elegans muscle component Titin, is reduced in nfi-1 mutant animals. | Paper_evidence | WBPaper00003438 | |||||
| WBPaper00026912 | |||||||||
| WBPaper00032048 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Jul 2008 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of egg-laying behavior; and regulation of pharyngeal pumping. Acts upstream of or within determination of adult lifespan. Predicted to be located in nucleus. Expressed in several structures, including body wall musculature; egg-laying apparatus; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome; NFIA-related disorder; and Sotos syndrome 2. Is an ortholog of human NFIA (nuclear factor I A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7788) | ||||
| DOID:0060409 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7784) | ||||||
| DOID:0050858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7788) | ||||||
| Molecular_info | Corresponding_CDS | ZK1290.4a | |||||||
| ZK1290.4b | |||||||||
| ZK1290.4c | |||||||||
| Corresponding_CDS_history | ZK1290.4:wp86 | ||||||||
| ZK1290.4:wp130 | |||||||||
| ZK1290.4:wp137 | |||||||||
| Corresponding_transcript | ZK1290.4a.1 | ||||||||
| ZK1290.4b.1 | |||||||||
| ZK1290.4b.2 | |||||||||
| ZK1290.4b.3 | |||||||||
| ZK1290.4c.1 | |||||||||
| Other_sequence | JI165653.1 | ||||||||
| CR08418 | |||||||||
| CRC02685_1 | |||||||||
| CBC09830_1 | |||||||||
| JI475212.1 | |||||||||
| Associated_feature | WBsf644388 | ||||||||
| WBsf657171 | |||||||||
| WBsf221606 | |||||||||
| WBsf221607 | |||||||||
| Gene_product_binds (56) | |||||||||
| Transcription_factor | WBTranscriptionFactor000134 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00021867 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00059213 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075897 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024297 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008274 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4339 | ||||||||
| Expr8225 | |||||||||
| Expr9759 | |||||||||
| Expr9802 | |||||||||
| Expr10997 | |||||||||
| Expr1021363 | |||||||||
| Expr1031641 | |||||||||
| Expr1162632 | |||||||||
| Expr2013983 | |||||||||
| Expr2032223 | |||||||||
| Drives_construct | WBCnstr00013191 | ||||||||
| WBCnstr00014279 | |||||||||
| WBCnstr00014322 | |||||||||
| WBCnstr00017845 | |||||||||
| WBCnstr00018071 | |||||||||
| WBCnstr00036018 | |||||||||
| Construct_product | WBCnstr00013191 | ||||||||
| WBCnstr00014322 | |||||||||
| WBCnstr00018071 | |||||||||
| WBCnstr00036018 | |||||||||
| Antibody | WBAntibody00001951 | ||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (95) | |||||||||
| Interaction (49) | |||||||||
| Map_info | Map | II | Position | 0.504048 | Error | 0.0001 | |||
| Positive | Positive_clone | ZK1290 | Person_evidence | WBPerson221 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 5523 | |||||||
| 4797 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
