WormBase Tree Display for Gene: WBGene00003593
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| WBGene00003593 | Evidence | Person_evidence | WBPerson204 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F42A10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | nfm-1 | Person_evidence | WBPerson204 | |||||
| Sequence_name | F42A10.2 | ||||||||
| Molecular_name | F42A10.2a | ||||||||
| F42A10.2a.1 | |||||||||
| CE01293 | |||||||||
| F42A10.2b | |||||||||
| CE26892 | |||||||||
| F42A10.2c | |||||||||
| CE37913 | |||||||||
| F42A10.2b.1 | |||||||||
| F42A10.2c.1 | |||||||||
| Other_name | CELE_F42A10.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | nfm-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nfm | ||||||||
| Allele (60) | |||||||||
| Strain | WBStrain00035868 | ||||||||
| WBStrain00054852 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00001333 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WBGene00008555 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | nfm-1 encodes a homolog of human merlin/schwannomin (NF2), which when mutated leads to neurofibromatosis, type 2 (OMIM:101000); at the same time, it is also homologous to the ERM family of cytoskeletal linkers with approximately equal similarity to ezrin, radixin and moesin. | Paper_evidence | WBPaper00004103 | |||||
| Person_evidence | WBPerson204 | ||||||||
| Curator_confirmed | WBPerson13481 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin binding activity and integrin binding activity. Predicted to be involved in several processes, including regulation of cellular localization; regulation of gliogenesis; and regulation of hippo signaling. Predicted to be located in several cellular components, including adherens junction; apical part of cell; and filopodium. Expressed in excretory gland cell; gonadal sheath cell; intestinal cell; pharyngeal muscle cell; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| DOID:9253 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| DOID:0111252 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| DOID:12689 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| DOID:3565 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| DOID:3192 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| DOID:7474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| DOID:4586 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7773) | ||||||
| Molecular_info | Corresponding_CDS | F42A10.2a | |||||||
| F42A10.2b | |||||||||
| F42A10.2c | |||||||||
| Corresponding_transcript | F42A10.2a.1 | ||||||||
| F42A10.2b.1 | |||||||||
| F42A10.2c.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf658520 | ||||||||
| WBsf992663 | |||||||||
| WBsf992664 | |||||||||
| WBsf1015042 | |||||||||
| WBsf225060 | |||||||||
| WBsf225061 | |||||||||
| WBsf225062 | |||||||||
| WBsf225063 | |||||||||
| WBsf225064 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00011050 | ||||||||
| WBCnstr00036017 | |||||||||
| WBCnstr00038305 | |||||||||
| WBCnstr00041555 | |||||||||
| Construct_product | WBCnstr00011050 | ||||||||
| WBCnstr00036017 | |||||||||
| WBCnstr00038304 | |||||||||
| WBCnstr00038306 | |||||||||
| WBCnstr00038307 | |||||||||
| WBCnstr00041555 | |||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (155) | |||||||||
| Interaction (32) | |||||||||
| Map_info | Map | III | Position | -1.41215 | Error | 0.000583 | |||
| Positive | Positive_clone | F42A10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4407 | |||||||
| 4457 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00019551 | ||||||||
| WBPaper00024233 | |||||||||
| WBPaper00024261 | |||||||||
| WBPaper00026515 | |||||||||
| WBPaper00027245 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00045213 | |||||||||
| WBPaper00050480 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00057136 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
