WormBase Tree Display for Gene: WBGene00003901
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| WBGene00003901 | Evidence | Author_evidence | Ogura K-i | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F48E8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | paa-1 | Person_evidence | WBPerson211 | |||||
| Sequence_name | F48E8.5 | ||||||||
| Molecular_name | F48E8.5 | ||||||||
| F48E8.5.1 | |||||||||
| CE30997 | |||||||||
| Other_name | CELE_F48E8.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | paa-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | paa | ||||||||
| Allele (35) | |||||||||
| Strain | WBStrain00001224 | ||||||||
| WBStrain00001223 | |||||||||
| WBStrain00036337 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP3304 | ||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00008878 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | paa-1 encodes the sole C. elegans homolog of PR65, the structural subunit of protein phosphatase 2A (PP2A); paa-1 is an essential gene, required in RNAi assays for embryonic viability, fertility, and cuticular integrity; PAA-1 protein physically interacts with LET-92, the PP2A catalytic subunit, and with RSA-1, a PP2A regulatory subunit; PAA-1 also physically interacts with SMG-5; PAA-1 localizes to centrosomes, the mitotic spindle, P granules, and the nuclear envelope; PAA-1 levels at the centrosome are decreased in rsa-1 mutant animals. | Paper_evidence | WBPaper00005723 | |||||
| WBPaper00012850 | |||||||||
| WBPaper00041923 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 22 Jan 2012 00:00:00 | ||||||||
| Automated_description | Enables DEAD/H-box RNA helicase binding activity. Involved in embryo development. Located in P granule; microtubule cytoskeleton; and nuclear envelope. Part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Is an ortholog of human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha) and PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070066 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9302) | ||||
| Molecular_info | Corresponding_CDS | F48E8.5 | |||||||
| Corresponding_transcript | F48E8.5.1 | ||||||||
| Other_sequence (136) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Expr6114 | ||||||||
| Expr6115 | |||||||||
| Expr10619 | |||||||||
| Expr14272 | |||||||||
| Expr15730 | |||||||||
| Expr1020049 | |||||||||
| Expr1031838 | |||||||||
| Expr1151586 | |||||||||
| Expr2014673 | |||||||||
| Expr2032906 | |||||||||
| Drives_construct | WBCnstr00002116 | ||||||||
| WBCnstr00002117 | |||||||||
| Antibody | WBAntibody00002401 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (100) | |||||||||
| Interaction (210) | |||||||||
| Map_info | Map | III | Position | -1.65971 | Error | 0.012666 | |||
| Positive | Positive_clone | F48E5 | Inferred_automatically | From CDS info | |||||
| F48E8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
