WormBase Tree Display for Gene: WBGene00003943
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| WBGene00003943 | Evidence | Paper_evidence | WBPaper00005421 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K09C8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pbo-4 | Person_evidence | WBPerson655 | |||||
| Sequence_name | K09C8.1 | ||||||||
| Molecular_name | K09C8.1 | ||||||||
| K09C8.1.1 | |||||||||
| CE31034 | |||||||||
| Other_name | nhx-7 | Person_evidence | WBPerson298 | ||||||
| Author_evidence | Santo P D | ||||||||
| CELE_K09C8.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | pbo-4 | ||||||||
| DB_info | Database | AceView | gene | XL575 | |||||
| WormQTL | gene | WBGene00003943 | |||||||
| WormFlux | gene | WBGene00003943 | |||||||
| NDB | locus_tag | CELE_K09C8.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003943|UniProtKB=G5EBK1 | |||||||
| family | PTHR10110 | ||||||||
| NCBI | gene | 181285 | |||||||
| RefSeq | protein | NM_077429.9 | |||||||
| SwissProt | UniProtAcc | G5EBK1 | |||||||
| TREEFAM | TREEFAM_ID | TF317212 | |||||||
| UniProt_GCRP | UniProtAcc | G5EBK1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pbo | ||||||||
| Allele (73) | |||||||||
| Legacy_information | [C.elegansII] sa300 : pBoc weak but often present, slightly constipated, non-Egl, apparently normal feeding.NA1. [JT] | ||||||||
| Strain | WBStrain00006658 | ||||||||
| WBStrain00031506 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00003729 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003730 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003731 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003732 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003733 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003734 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003735 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003736 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pbo-4 encodes a Na+/H+ ion exchanger (NHE) most closely related to mammalian NHE1 that promotes extracellular acidification (and intracellular alkalinization) by catalyzing the electroneutral exchange of one extracellular Na+ ion for one intracellular H+ ion; in C. elegans, PBO-4 functions cell autonomously in the intestine to regulate normal posterior body wall muscle contractions (pBoc) during the defecation cycle; expressed in the basolateral membrane of posterior intestinal cells, PBO-4 regulates the pBoc step of the defecation cycle by promoting H+ secretion from intestinal cells that, in turn, activates a PBO-5/PBO-6 proton-gated, cys-loop cation channel expressed in adjacent posterior body wall muscle cells; based on sequence similarity to mammalian NHE1, the carboxy-terminal region of PBO-4 contains a number of potential regulatory sites, including predicted PIP2- and CaM-binding sites, as well as potential CamKII and PKC phosphorylation sites. | Paper_evidence | WBPaper00005421 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00031426 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 11 Jul 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Involved in several processes, including defecation; lipid transport involved in lipid storage; and positive regulation of multicellular organismal process. Located in basolateral plasma membrane. Expressed in intestine. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K09C8.1 | |||||||
| Corresponding_CDS_history | K09C8.1:wp80 | ||||||||
| Corresponding_transcript | K09C8.1.1 | ||||||||
| Other_sequence | AF497831 | ||||||||
| ACC32324_1 | |||||||||
| FC549154.1 | |||||||||
| FC816129.1 | |||||||||
| CR10619 | |||||||||
| SR02665 | |||||||||
| CR06508 | |||||||||
| FC548331.1 | |||||||||
| CRC00773_1 | |||||||||
| SRC10587_1 | |||||||||
| Associated_feature | WBsf663287 | ||||||||
| WBsf236317 | |||||||||
| WBsf236318 | |||||||||
| WBsf236319 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr2235 | ||||||||
| Expr2242 | |||||||||
| Expr7877 | |||||||||
| Expr1024495 | |||||||||
| Expr1031872 | |||||||||
| Expr1154103 | |||||||||
| Expr2014761 | |||||||||
| Expr2032995 | |||||||||
| Drives_construct | WBCnstr00006698 | ||||||||
| WBCnstr00010714 | |||||||||
| WBCnstr00010722 | |||||||||
| WBCnstr00012964 | |||||||||
| WBCnstr00035783 | |||||||||
| Construct_product | WBCnstr00010722 | ||||||||
| WBCnstr00012964 | |||||||||
| WBCnstr00035783 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (175) | |||||||||
| Interaction | WBInteraction000225940 | ||||||||
| WBInteraction000286572 | |||||||||
| WBInteraction000343940 | |||||||||
| WBInteraction000382943 | |||||||||
| WBInteraction000388626 | |||||||||
| WBInteraction000519695 | |||||||||
| WBInteraction000519700 | |||||||||
| WBInteraction000519707 | |||||||||
| WBInteraction000551603 | |||||||||
| WBInteraction000583074 | |||||||||
| Map_info | Map | X | Position | 2.71969 | Error | 0.007321 | |||
| Positive | Positive_clone | K09C8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4566 | |||||||
| 4578 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Sequence connection from [Nehrke K, Melvin J] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
