WormBase Tree Display for Gene: WBGene00004010
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WBGene00004010 | SMap | S_parent | Sequence | CHROMOSOME_III | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pha | ||||||
Allele (70) | |||||||
Legacy_information | See also e2123, e2275, e2286, e2468 | ||||||
[C.elegansII] e2123ts : at 25C zygotic embryonic lethal, pharynx fails to undergo late differentiation and morphogenesis; early pharynx development normal. OA>5: e2468 (unconditional), t1001ts,e2286 (weak, 38% hatch and arrest), t1002 (weak,some survival to late larval arrest), etc.See also extragenic suppressors sup-35, sup-36, sup-37. Cloned: 2.2kb embryonic transcript, encodes 491 aa predicted protein with some similarity to bZIP transcription factors; pha-1:lacZ expressed transiently in all pharyngeal precursor cells. [Granato et al. 1994; GE] | |||||||
Strain (593) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (19) | |||||||
Ortholog (20) | |||||||
Paralog (14) | |||||||
Structured_description | Concise_description | pha-1 encodes a novel protein that contains a DUF1114 domain of unknown function found in a number of other nematode proteins; during embryonic development, pha-1 functions redundantly with class B SynMuv genes such as lin-35/Rb and efl-1 to effect pharyngeal morphogenesis; in regulating pharyngeal development, PHA-1 also appears to act with the UBC-18 ubiquitin conjugating enzyme; a PHA-1::GFP reporter is broadly expressed during embryonic development and localizes to the cytoplasm; expression is also observed in early- and late-larval-stage animals, as well as adults, although postembryonic expression is generally weaker than that seen in the embryo. | Paper_evidence | WBPaper00001348 | |||
WBPaper00002047 | |||||||
WBPaper00024215 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 02 Jul 2007 00:00:00 | ||||||
Automated_description | Predicted to enable alpha-(1->3)-fucosyltransferase activity. Involved in embryonic digestive tract morphogenesis; nematode larval development; and reproduction. Located in cytoplasm. Expressed in body wall muscle cell and pharynx. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y48A6C.5a | |||||
Y48A6C.5b | |||||||
Corresponding_transcript | Y48A6C.5a.1 | ||||||
Y48A6C.5b.1 | |||||||
Other_sequence | X73845 | ||||||
Associated_feature | WBsf994278 | ||||||
WBsf994279 | |||||||
WBsf1015931 | |||||||
WBsf1015932 | |||||||
WBsf225796 | |||||||
WBsf225797 | |||||||
Transcription_factor | WBTranscriptionFactor000527 | ||||||
Experimental_info | RNAi_result (34) | ||||||
Expr_pattern | Expr1579 | ||||||
Expr2985 | |||||||
Expr1025653 | |||||||
Expr1031918 | |||||||
Expr1160324 | |||||||
Expr2014879 | |||||||
Expr2033114 | |||||||
Drives_construct | WBCnstr00000210 | ||||||
WBCnstr00000211 | |||||||
WBCnstr00000212 | |||||||
WBCnstr00010343 | |||||||
WBCnstr00011064 | |||||||
WBCnstr00014859 | |||||||
WBCnstr00018920 | |||||||
WBCnstr00019419 | |||||||
WBCnstr00022365 | |||||||
Construct_product (13) | |||||||
Microarray_results (23) | |||||||
Expression_cluster (69) | |||||||
Interaction (57) | |||||||
Map_info | Map | III | Position | 6.14398 | Error | 0.074527 | |
Well_ordered | |||||||
Positive | Inside_rearr | tDf1 | |||||
tDp1 | |||||||
tDp2 | |||||||
Positive_clone | CB#H8J04 | ||||||
Y48A6C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 1248 | |||||
1249 | |||||||
2786 | |||||||
4392 | |||||||
Pos_neg_data | 5729 | ||||||
5738 | |||||||
5949 | |||||||
8415 | |||||||
Reference (95) | |||||||
Method | Gene |