WormBase Tree Display for Gene: WBGene00004033
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| WBGene00004033 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pkc-2 | Person_evidence | WBPerson1505 | |||||
| Sequence_name | E01H11.1 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | kin-11 | ||||||||
| PKC2A | Accession_evidence | EMBL | U82935 | ||||||
| PKC2B | Accession_evidence | EMBL | U82936 | ||||||
| CELE_E01H11.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | pkc-2 | ||||||||
| DB_info | Database (15) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 07 Nov 2007 17:17:01 | WBPerson1867 | Event | Acquires_merge | WBGene00044688 | ||||
| Acquires_merge | WBGene00044688 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pkc | ||||||||
| Allele (363) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes two isoforms of protein kinase C2, PKC2A and PKC2B. Clone CR#PKC2A, cosmid E01H11[CR] | ||||||||
| Strain | WBStrain00003316 | ||||||||
| WBStrain00035524 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (49) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | pkc-2 encodes protein kinases similar to the classical protein kinase C family of Ca2+/diacylglycerol-stimulated kinases; when expressed in insect cells, one PKC-2 isoform exhibits Ca2+-dependent serine phosphorylation; PKC-2 isoforms are expressed in neurons, the intestine, muscles cells, and the somatic distal gonad, including the spermatheca; in neurons, PKC-2 localizes to the cell body and to neuronal processes; PKC-2 is expressed at low levels in embryos, with expression increasing 10-fold during the L1 larval stage, and then continuing at lower levels throughout post-embryonic development; fractionation experiments indicate that in young adults and mid-L1 and L2 larvae, PKC-2 isoforms are nearly evenly distributed between the cytosol and organelles and/or the cytoskeleton; in egg-laying adults, approximately 70% of PKC-2 is found in the cytosol. | Paper_evidence | WBPaper00002733 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 22 May 2012 00:00:00 | ||||||||
| Automated_description | Enables calcium-dependent protein kinase C activity and protein serine kinase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cytosol; neuron projection; and neuronal cell body. Expressed in body wall musculature; intestine; neurons; somatic nervous system; and tail ganglion. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; brain disease (multiple); carcinoma (multiple); and ductal carcinoma in situ. Is an ortholog of human PRKCA (protein kinase C alpha) and PRKCB (protein kinase C beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (14) | ||||||||
| Disease_relevance | pkc-2 is orthologous to human genes in the protein kinase C (PKC) family; mutations in protein kinase C, alpha (PRKCA) have been implicated in pituitary tumors; mutations in protein kinase C, gamma (PRKCG) have been implicated in Spinocerebellar ataxia. | Homo sapiens | Paper_evidence | WBPaper00002733 | |||||
| Accession_evidence | OMIM | 176960 | |||||||
| 176980 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Feb 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | E01H11.1a | |||||||
| E01H11.1b | |||||||||
| E01H11.1c | |||||||||
| E01H11.1d | |||||||||
| E01H11.1e | |||||||||
| E01H11.1f | |||||||||
| Corresponding_CDS_history | E01H11.1c:wp271 | ||||||||
| Corresponding_transcript | E01H11.1a.1 | ||||||||
| E01H11.1b.1 | |||||||||
| E01H11.1c.1 | |||||||||
| E01H11.1d.1 | |||||||||
| E01H11.1e.1 | |||||||||
| E01H11.1f.1 | |||||||||
| Other_sequence (65) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram893 | ||||||||
| Expr1618 | |||||||||
| Expr13412 | |||||||||
| Expr13413 | |||||||||
| Expr1020221 | |||||||||
| Expr1031935 | |||||||||
| Expr1147568 | |||||||||
| Expr2014945 | |||||||||
| Expr2033180 | |||||||||
| Drives_construct | WBCnstr00003787 | ||||||||
| WBCnstr00035732 | |||||||||
| WBCnstr00039449 | |||||||||
| WBCnstr00039450 | |||||||||
| Construct_product | WBCnstr00035732 | ||||||||
| Antibody | WBAntibody00001800 | ||||||||
| Microarray_results (56) | |||||||||
| Expression_cluster (225) | |||||||||
| Interaction (173) | |||||||||
| Map_info | Map | X | Position | 1.13958 | Error | 0.015727 | |||
| Positive | Positive_clone | CR#PKC2A | |||||||
| E01H11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4587 | |||||||
| 5438 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (41) | |||||||||
| Remark | The kin-11 gene was merged into this gene following suggestion by Jonathan Hodgkin. krb 27/02/02 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
