WormBase Tree Display for Gene: WBGene00004042
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WBGene00004042 | SMap | S_parent | Sequence | C14B9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | plk | ||||||
Allele (38) | |||||||
Strain | WBStrain00036529 | ||||||
WBStrain00007114 | |||||||
WBStrain00007364 | |||||||
WBStrain00029235 | |||||||
WBStrain00022403 | |||||||
WBStrain00022408 | |||||||
WBStrain00022414 | |||||||
WBStrain00022416 | |||||||
WBStrain00054974 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (58) | |||||||
Ortholog (42) | |||||||
Paralog | WBGene00004043 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00004044 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | plk-1 encodes a serine/threonine polo-like kinase homologous to Drosophila polo and Saccharomyces cerevisiae CDC5; during development, plk-1 functions to regulate meiotic cell cycle progression as well as embryonic cytoplasmic polarity in newly fertilized embryos and possibly germline development; specifically, plk-1 is required for meiotic nuclear envelope breakdown, polar body formation and extrusion, and proper chromosome segregation during meiosis possibly via phosphorylation and subsequent degradation of REC-8, a meiotic-specific cohesin; in regulating embryonic polarity, PLK-1 functions to regulate activity of the MEX-5/6 zinc-finger proteins, with which it interacts, via its polo box domain, in yeast two-hybrid assays; PLK-1 is localized diffusely in the cytoplasm of mature oocytes, but during meiosis I becomes associated with pre-metaphase chromatin and then at anaphase with chromatin and the area between dividing chromatin; in embryos, PLK-1 localizes to the cytoplasm of somatic blastomeres and during mitosis, to centrosomes, metaphase chromatin and, at telophase, to the area between dividing chromatin; the asymmetric localization of PLK-1 to somatic cytoplasm of early embryos is dependent upon the PAR proteins and MEX-5/6. | Paper_evidence | WBPaper00004215 | |||
WBPaper00031434 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 12 Aug 2008 00:00:00 | ||||||
Automated_description | Enables protein serine/threonine kinase activity. Involved in organelle organization; positive regulation of nematode male tail tip morphogenesis; and regulation of cell cycle. Located in several cellular components, including condensed chromosome; microtubule cytoskeleton; and nucleus. Expressed in AB and embryonic cell. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Is an ortholog of human PLK1 (polo like kinase 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:10286 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||
DOID:289 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||
DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||
DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||
DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||
Molecular_info | Corresponding_CDS | C14B9.4 | |||||
Corresponding_CDS_history | C14B9.4b:wp275 | ||||||
Corresponding_transcript | C14B9.4.1 | ||||||
Other_sequence (62) | |||||||
Associated_feature | WBsf645386 | ||||||
WBsf993240 | |||||||
WBsf993241 | |||||||
WBsf1015356 | |||||||
WBsf1015357 | |||||||
WBsf225347 | |||||||
Experimental_info | RNAi_result (32) | ||||||
Expr_pattern (17) | |||||||
Drives_construct | WBCnstr00020528 | ||||||
WBCnstr00020529 | |||||||
WBCnstr00035725 | |||||||
Construct_product | WBCnstr00004713 | ||||||
WBCnstr00004714 | |||||||
WBCnstr00004715 | |||||||
WBCnstr00004716 | |||||||
WBCnstr00004730 | |||||||
WBCnstr00007535 | |||||||
WBCnstr00020528 | |||||||
WBCnstr00020529 | |||||||
WBCnstr00035725 | |||||||
Antibody | WBAntibody00000294 | ||||||
WBAntibody00001379 | |||||||
WBAntibody00002275 | |||||||
WBAntibody00002743 | |||||||
WBAntibody00002789 | |||||||
WBAntibody00002892 | |||||||
WBAntibody00002960 | |||||||
Microarray_results (25) | |||||||
Expression_cluster (204) | |||||||
SAGE_tag (19) | |||||||
Interaction (1090) | |||||||
WBProcess | WBbiopr:00000068 | ||||||
Map_info | Map | III | Position | -0.377121 | Error | 0.000162 | |
Positive | Positive_clone | C14B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
K06H7 | |||||||
Pseudo_map_position | |||||||
Reference (86) | |||||||
Remark | annotated as plc1 in the EMBLGenbank record. sdm 12/00 | ||||||
K06H7.1 removed. sdm 12/00 | |||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |