WormBase Tree Display for Gene: WBGene00004202
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| WBGene00004202 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C37A5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pry-1 | Person_evidence | WBPerson1157 | |||||
| Sequence_name | C37A5.9 | ||||||||
| Molecular_name | C37A5.9 | ||||||||
| C37A5.9.1 | |||||||||
| CE30125 | |||||||||
| Other_name | Axin | Paper_evidence | WBPaper00044307 | ||||||
| CELE_C37A5.9 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | pry-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pry | ||||||||
| Allele (164) | |||||||||
| Possibly_affected_by | WBVar02153203 | ||||||||
| Legacy_information (2) | |||||||||
| Strain | WBStrain00023614 | ||||||||
| WBStrain00030966 | |||||||||
| WBStrain00004827 | |||||||||
| WBStrain00024333 | |||||||||
| WBStrain00047536 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (59) | |||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | pry-1 encodes a protein containing RGS and DIX domains that is distantly related to members of the Axin family of proteins that function as part of a complex that targets beta-catenin for destruction in the absence of Wnt signaling; during C. elegans development, PRY-1 functions as a negative regulator of Wnt signaling pathways that specify cell fates during asymmetric cell division; in addition, pry-1 has been shown to have a role in axon guidance; PRY-1 physically interacts with BAR-1, SGG-1, APR-1, and AXL-1; PRY-1 reporter fusion proteins are expressed in hypodermal and neuronal lineages where they typically localize asymmetrically to the anterior cortex. | Paper_evidence | WBPaper00003383 | |||||
| WBPaper00005278 | |||||||||
| WBPaper00028984 | |||||||||
| WBPaper00029082 | |||||||||
| WBPaper00030820 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Feb 2009 00:00:00 | ||||||||
| Automated_description | Enables ubiquitin ligase-substrate adaptor activity. Involved in several processes, including axon guidance; negative regulation of vulval development; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cell cortex; membrane; and nucleus. Part of beta-catenin destruction complex. Expressed in several structures, including QL.a; hypodermal cell; neurons; ventral cord blast cell; and vulval precursor cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C37A5.9 | |||||||
| Corresponding_CDS_history | C37A5.9:wp71 | ||||||||
| Corresponding_transcript | C37A5.9.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf665111 | ||||||||
| WBsf986083 | |||||||||
| WBsf1011197 | |||||||||
| WBsf220586 | |||||||||
| WBsf220587 | |||||||||
| WBsf220588 | |||||||||
| Experimental_info | RNAi_result (63) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00000302 | ||||||||
| WBCnstr00000614 | |||||||||
| WBCnstr00012109 | |||||||||
| WBCnstr00016100 | |||||||||
| WBCnstr00019338 | |||||||||
| WBCnstr00022520 | |||||||||
| WBCnstr00042081 | |||||||||
| WBCnstr00042220 | |||||||||
| Construct_product | WBCnstr00012109 | ||||||||
| WBCnstr00016100 | |||||||||
| WBCnstr00042081 | |||||||||
| WBCnstr00042082 | |||||||||
| WBCnstr00042083 | |||||||||
| WBCnstr00042084 | |||||||||
| WBCnstr00042220 | |||||||||
| Regulate_expr_cluster | WBPaper00055626:pry-1(mu38)_downregulated | ||||||||
| WBPaper00055626:pry-1(mu38)_upregulated | |||||||||
| WBPaper00057033:pry-1(mu38)_downregulated | |||||||||
| WBPaper00057033:pry-1(mu38)_upregulated | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (191) | |||||||||
| Map_info | Map | I | Position | 23.6118 | Error | 0.064259 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C37A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3241 | |||||||
| 3242 | |||||||||
| 4451 | |||||||||
| 4793 | |||||||||
| Pos_neg_data | 8537 | ||||||||
| Reference (88) | |||||||||
| Picture | WBPicture0000013083 | ||||||||
| Remark | Sequence connection from [Korswagen H] | ||||||||
| Method | Gene |
