WormBase Tree Display for Gene: WBGene00004393
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WBGene00004393 | SMap | S_parent | Sequence | B0414 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | rnt | ||||||
Reference_allele | WBVar00143855 | ||||||
Allele (143) | |||||||
Legacy_information | e1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages bursa often grossly distorted. ME0/ME1. Hermaphrodite gross phenotype normal late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1. | ||||||
See also e1241 | |||||||
[C.elegansII] e1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages; bursa often grossly distorted. ME0/ME1. Hermaphrodite gross phenotype normal; late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1. [Hodgkin 1983a; Link et al. 1988; CB] | |||||||
Strain | WBStrain00035360 | ||||||
WBStrain00035361 | |||||||
WBStrain00035362 | |||||||
WBStrain00040727 | |||||||
WBStrain00001748 | |||||||
WBStrain00035579 | |||||||
WBStrain00004456 | |||||||
WBStrain00008477 | |||||||
WBStrain00051045 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (36) | |||||||
Ortholog (46) | |||||||
Structured_description | Concise_description | rnt-1 encodes a transcription factor that is the sole C. elegans member of the Runx family of transcriptional regulators; rnt-1 activity is required for several developmental processes, including regulation of hypodermal seam cell proliferation and proper development of the male tail; rnt-1 mutant animals also exhibit a slight reduction in body size which is enhanced by starvation; RNT-1 can physically interact with SMA-4 and regulates, either directly or indirectly, expression of tlp-1 and cki-1, which encode a C2H2 zinc finger and CDK inhibitor, respectively; RNT-1::GFP reporter fusions are expressed in the nuclei of hypodermal seam cells and transiently in body wall muscles; in males, a RNT-1::GFP is expressed in cells derived from the V5, V6 and T lineages that give rise to the sensory rays. | Paper_evidence | WBPaper00005040 | |||
WBPaper00024401 | |||||||
WBPaper00026860 | |||||||
WBPaper00026868 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 03 Jan 2011 00:00:00 | ||||||
Automated_description | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of locomotion involved in locomotory behavior; and regulation of gene expression. Acts upstream of or within dopamine metabolic process. Located in nucleus. Part of core-binding activity factor complex. Expressed in body wall musculature; intestine; neurons; ray precursor cell; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and osteochondrodysplasia (multiple). Is an ortholog of human RUNX2 (RUNX family transcription factor 2) and RUNX3 (RUNX family transcription factor 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (23) | ||||||
Molecular_info | Corresponding_CDS | B0414.2 | |||||
Corresponding_transcript | B0414.2.1 | ||||||
B0414.2.2 | |||||||
B0414.2.3 | |||||||
Other_sequence | CBC12954_1 | ||||||
Associated_feature (23) | |||||||
Transcription_factor | WBTranscriptionFactor000199 | ||||||
Experimental_info | RNAi_result | WBRNAi00065557 | Inferred_automatically | RNAi_primary | |||
WBRNAi00039038 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00028240 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00063834 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00064608 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00063835 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00002853 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00001354 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (22) | |||||||
Drives_construct (13) | |||||||
Construct_product | WBCnstr00010470 | ||||||
WBCnstr00011148 | |||||||
WBCnstr00012390 | |||||||
WBCnstr00012969 | |||||||
WBCnstr00016840 | |||||||
WBCnstr00018817 | |||||||
WBCnstr00018818 | |||||||
WBCnstr00022571 | |||||||
WBCnstr00035514 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (119) | |||||||
Interaction (127) | |||||||
WBProcess | WBbiopr:00000025 | ||||||
WBbiopr:00000073 | |||||||
WBbiopr:00000112 | |||||||
Map_info | Map | I | Position | 0.447019 | Error | 0.000263 | |
Positive | Positive_clone | B0414 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 329 | |||||
Multi_point | 205 | ||||||
4641 | |||||||
5090 | |||||||
Reference (75) | |||||||
Remark | |||||||
Method | Gene |