WormBase Tree Display for Gene: WBGene00004738
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| WBGene00004738 | SMap | S_parent | Sequence | F18E2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | scc-3 | Person_evidence | WBPerson421 | |||||
| Sequence_name | F18E2.3 | ||||||||
| Molecular_name | F18E2.3 | ||||||||
| F18E2.3.1 | |||||||||
| CE05664 | |||||||||
| Other_name | CELE_F18E2.3 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | scc-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | scc | ||||||||
| Allele (54) | |||||||||
| Strain | WBStrain00026528 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (51) | |||||||||
| Structured_description | Concise_description | scc-3 encodes a cohesin complex subunit homologous to Saccharomyces cerevisiae Irr1p/Scc3p; SCC-3 is required during meiosis for synaptonemal complex formation and sister chromatid cohesion, proper localization of REC-8 to chromosomes, mitotic chromosome segregation, embryonic development, and vulval morphogenesis; in embryos, SCC-3 forms a cohesin complex with SCC-1, SMC-1, SMC-3, and TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS; in the germline, SCC-3 associates with chromatin of transistion zone nuclei, assembles along the longitudinal axes of synapsed chromosomes at pachytene, and unlike other cohesins, localizes throughout chromatin at diakinesis; SCC-3 localization requires TIM-1, and SCC-3 and REC-8 are mutually required for chromatin localization. | Paper_evidence | WBPaper00005919 | |||||
| WBPaper00005937 | |||||||||
| WBPaper00006163 | |||||||||
| WBPaper00018756 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA binding activity and chromatin binding activity. Involved in organelle organization and regulation of DNA damage checkpoint. Located in condensed chromosome. Part of chromatin and cohesin complex. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including intellectual disability (multiple); primary ovarian insufficiency 8; and spermatogenic failure 61. Is an ortholog of human STAG1 (STAG1 cohesin complex component) and STAG2 (STAG2 cohesin complex component). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112350 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11356) | ||||
| DOID:0111845 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11355) | ||||||
| DOID:0080865 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11356) | ||||||
| DOID:0080238 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11354) | ||||||
| DOID:4621 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11355) | ||||||
| Molecular_info | Corresponding_CDS | F18E2.3 | |||||||
| Corresponding_transcript | F18E2.3.1 | ||||||||
| Other_sequence | JI165410.1 | ||||||||
| CJC02499_1 | |||||||||
| JI464327.1 | |||||||||
| CJC00773_1 | |||||||||
| JI471510.1 | |||||||||
| Acan_isotig21551 | |||||||||
| Dviv_isotig16225 | |||||||||
| CBC15731_1 | |||||||||
| Tcol_isotig13433 | |||||||||
| CRC12241_1 | |||||||||
| Associated_feature | WBsf647406 | ||||||||
| WBsf661932 | |||||||||
| WBsf661933 | |||||||||
| WBsf661934 | |||||||||
| WBsf232696 | |||||||||
| WBsf232697 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr2676 | ||||||||
| Expr1022470 | |||||||||
| Expr1032338 | |||||||||
| Expr1148911 | |||||||||
| Expr2015622 | |||||||||
| Expr2033857 | |||||||||
| Drives_construct | WBCnstr00035419 | ||||||||
| Construct_product | WBCnstr00035419 | ||||||||
| Antibody | WBAntibody00000637 | ||||||||
| WBAntibody00000675 | |||||||||
| WBAntibody00000676 | |||||||||
| WBAntibody00000836 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (108) | |||||||||
| Interaction (130) | |||||||||
| WBProcess | WBbiopr:00000099 | ||||||||
| Map_info | Map | V | Position | 4.67516 | Error | 0.009823 | |||
| Positive | Positive_clone | F18E2 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4308 | |||||||
| 4650 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
