WormBase Tree Display for Gene: WBGene00004786
expand all nodes | collapse all nodes | view schema
WBGene00004786 | Evidence | Paper_evidence | WBPaper00003081 | ||||
---|---|---|---|---|---|---|---|
WBPaper00003416 | |||||||
SMap | S_parent | Sequence | F44A6 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sex | ||||||
Allele (66) | |||||||
Legacy_information | sex-1 for Signal Element on X. sex-1 hermaphrodites are Dpy, Egl and Tra, males are wild type. Encodes predicted nuclear hormone receptor, gene F44A6.2,published as CNR14 by Kostrouch et al. (1995), aka nhr-24 | ||||||
Strain | WBStrain00028733 | ||||||
WBStrain00035136 | |||||||
WBStrain00036740 | |||||||
WBStrain00036791 | |||||||
WBStrain00036806 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (28) | |||||||
Ortholog (56) | |||||||
Paralog (217) | |||||||
Structured_description | Concise_description | sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males. | Paper_evidence | WBPaper00003262 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 12 Oct 2005 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in primary sex determination and regulation of gene expression. Located in nucleus. Expressed in gonad; intestine; oocyte; and ventral uterine precursor. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); liver disease (multiple); and lung carcinoma (multiple). Is an ortholog of human NR1D1 (nuclear receptor subfamily 1 group D member 1) and NR1D2 (nuclear receptor subfamily 1 group D member 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (27) | ||||||
Molecular_info | Corresponding_CDS | F44A6.2 | |||||
Corresponding_CDS_history | F44A6.2a:wp144 | ||||||
F44A6.2b:wp144 | |||||||
Corresponding_transcript | F44A6.2.1 | ||||||
Other_sequence | U13074 | ||||||
JI175482.1 | |||||||
EF066631.1 | |||||||
CR04735 | |||||||
AF367207.1 | |||||||
JI168358.1 | |||||||
CRC05784_1 | |||||||
Associated_feature (21) | |||||||
Transcription_factor | WBTranscriptionFactor000302 | ||||||
Experimental_info | RNAi_result (40) | ||||||
Expr_pattern | Expr1581 | ||||||
Expr7557 | |||||||
Expr8032 | |||||||
Expr15144 | |||||||
Expr1016094 | |||||||
Expr1032373 | |||||||
Expr1151099 | |||||||
Expr1200128 | |||||||
Expr2015785 | |||||||
Expr2034018 | |||||||
Drives_construct (2) | |||||||
Construct_product | WBCnstr00016585 | ||||||
WBCnstr00016774 | |||||||
WBCnstr00035389 | |||||||
Antibody | WBAntibody00000976 | ||||||
Microarray_results (25) | |||||||
Expression_cluster (193) | |||||||
Interaction (105) | |||||||
WBProcess | WBbiopr:00000056 | ||||||
Map_info | Map | X | Position | 1.8824 | Error | 0.018071 | |
Well_ordered | |||||||
Positive | Inside_rearr | stDp2 | |||||
Positive_clone | C06F4 | ||||||
F44A6 | Person_evidence | WBPerson600 | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4909 | |||||
Pos_neg_data | 9151 | ||||||
Reference (65) | |||||||
Remark | nhr-24 is predicted gene F44A6.2, pka cnr-14 | ||||||
sex-1 designation takes precedence, nhr-24 retired [021217 ck1] | |||||||
Method | Gene |