WormBase Tree Display for Gene: WBGene00004830
expand all nodes | collapse all nodes | view schema
| WBGene00004830 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y51A2D | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | slo-1 | Person_evidence | WBPerson689 | |||||
| Sequence_name | Y51A2D.19 | ||||||||
| Molecular_name (39) | |||||||||
| Other_name | nsy-3 | CGC_data_submission | |||||||
| CELE_Y51A2D.19 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | slo-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (11) | |||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00006275 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 Apr 2019 00:00:00 | ||||||||
| DOID:11723 | Homo sapiens | Paper_evidence | WBPaper00027149 | ||||||
| Accession_evidence | OMIM | 310200 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 12 Jun 2014 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6284) | |||||
| DOID:0111910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18867) | ||||||
| DOID:0070442 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6284) | ||||||
| DOID:1827 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6284) | ||||||
| Disease_relevance | Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; the C. elegans model for progressive myopathy consists of the elegans dystrophin/dys-1 mutation combined with a mutation in hlh-1, the MyoD ortholog (dys-1(cx18);hlh-1(cc561ts), these animals display time-dependent muscle degeneration; C. elegans mutants for slo-1 (cx29, cx42), which belongs to the family of BK (Slo) potassium channels activated synergistically by both intra-cellular calcium and voltage, exhibit hyperactivity similar to dys-1 mutants; when slo-1 is combined with the mutation in the MyoD/hlh-1 (hlh-1(cc561); slo-1(cx29)), the double mutant exhibits progressive muscle degeneration; further, slo-1 function and localization is dependent on the C. elegans dystrophin/dys-1; these studies in the worm model reveal dystrobrevin-dependent BK channel function involved in dystrophin-dystrobrevin associated diseases. | Homo sapiens | Paper_evidence | WBPaper00027149 | |||||
| Accession_evidence | OMIM | 310200 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 Jun 2014 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000294 | ||||||||
| WBDOannot00000656 | |||||||||
| WBDOannot00000657 | |||||||||
| WBDOannot00000658 | |||||||||
| WBDOannot00000659 | |||||||||
| WBDOannot00000660 | |||||||||
| Molecular_info | Corresponding_CDS (13) | ||||||||
| Corresponding_CDS_history | Y51A2D.19:wp74 | ||||||||
| Corresponding_transcript (13) | |||||||||
| Other_sequence (65) | |||||||||
| Associated_feature | WBsf1002916 | ||||||||
| WBsf1002917 | |||||||||
| WBsf1002918 | |||||||||
| WBsf1002919 | |||||||||
| WBsf1002920 | |||||||||
| WBsf1021484 | |||||||||
| WBsf1021485 | |||||||||
| WBsf1021486 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00113603 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00057136 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00037348 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007333 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (24) | |||||||||
| Construct_product (39) | |||||||||
| Antibody | WBAntibody00000436 | ||||||||
| Microarray_results (44) | |||||||||
| Expression_cluster (161) | |||||||||
| Interaction (35) | |||||||||
| Anatomy_function | WBbtf0240 | ||||||||
| WBbtf0241 | |||||||||
| WBbtf0242 | |||||||||
| Map_info | Map | V | Position | 16.7585 | Error | 0.028814 | |||
| Positive | Positive_clone | Y51A2D | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5030 | |||||||
| Reference (139) | |||||||||
| Remark | Updated Positive_clone tag from Y51A12, which looks like it might have been a typo. krb 11/03/02 | ||||||||
| Method | Gene |
